DegronMD

Uniprot ID: O15054

Source protein: Lysine-specific demethylase 6B

Source gene: KDM6B

Class: DEG_SPOP_SBC_1

Location: 394:398

E3 ligase: SPOP

DEGRON score: 0.9903

ASA_SCORE: 88.4

COIL: 0.9458

CONS_SCORE: 0.4275

DSS_SCORE: 0.73

HELIX: 0.0166

FCONS_SCORE: 1.0357

RIG_SCORE: 0.5622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S399T	TCGA-85-6560	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S399T	TCGA-D1-A1O7	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S399T	DO233259	GACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S399T	DO26752	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S399T	DO41139	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S405G	TCGA-BC-A10W	LIHC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1389
p.S405G	DO23002	LIHC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.S388F	TCGA-FW-A3R5	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1667
p.S388F	DO37406	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.T398S	TCGA-HU-A4G8	STAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.6005
p.T398S	DO47819	STAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.6005
p.T398S	SIDM01045	Endometrial Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.6005
p.T398S	ACH-000978	Endometrial/Uterine Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.6005
p.T397S	SIDM00845	Burkitt's Lymphoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.6005
p.A386V	SIDM00454	Rhabdomyosarcoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.N407S	SIDM00860	Head and Neck Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.S399I	SIDM00629	Breast Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.G395D	SIDM00217	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.6087
p.G395D	ACH-000999	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.6087
p.G395D	SNU-1040	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.6087
p.S406I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PGTTT	DEG_SPOP_SBC_1	0.5556
p.A386D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons