DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4082:4086

E3 ligase: SPOP

DEGRON score: 0.9542

ASA_SCORE: 84.28

COIL: 0.876

CONS_SCORE: 0.3323

DSS_SCORE: 0.8501

HELIX: 0.013

FCONS_SCORE: 1.118

RIG_SCORE: 0.4509

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4077K	TCGA-AP-A0LM	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1944
p.E4077K	TCGA-EI-6917	READ	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1944
p.P4082S	TCGA-B5-A1MX	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.6752
p.R4095K	TCGA-BF-A5EO	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0833
p.P4087L	TCGA-CM-6162	COAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.3056
p.G4083E	TCGA-D9-A6EA	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.6087
p.S4072G	TCGA-E7-A85H	BLCA	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S4075G	DO219018	BLCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.P4090L	DO8479	COAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T4094R	DO228618	GACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T4094R	DO228805	GACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T4094R	DO229024	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T4094R	DO229053	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T4094R	DO229006	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T4094R	DO231007	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T4094R	DO51470	PACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.P4083L	DO220851	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7582
p.R4077K	DO220857	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.G4086E	DO222632	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7199
p.G4086E	DO50290	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7199
p.E4080K	DO36881	READ	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.E4080K	DO43306	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.P4085S	DO41999	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.6752
p.A4092G	SIDM00871	Non-Cancerous	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A4092G	SIDM00872	Breast Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.E4077V	SIDM01102	Non-Cancerous	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.E4077V	ACH-002316	Non-Cancerous	CCLE	PGTTT	DEG_SPOP_SBC_1	0.1944
p.E4077V	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.P4087S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.P4087S	ACH-002222	Leukemia	CCLE	PGTTT	DEG_SPOP_SBC_1	0.3056
p.P4087S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S4081F	SK-CO-1	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PGTTT