DegronMD

Uniprot ID: Q8TDI7

Source protein: Transmembrane channel-like protein 2

Source gene: TMC2

Class: DEG_SCF_TRCP1_1

Location: 882:888

E3 ligase: BTRC

DEGRON score: 0.9597

ASA_SCORE: 73.4857

COIL: 0.9214

CONS_SCORE: 0.3413

DSS_SCORE: 0.8272

HELIX: 0.0559

FCONS_SCORE: 0.9217

RIG_SCORE: 0.4957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H885R	TCGA-CV-5430	HNSC	TCGA	DSGHAPS	DEG_SCF_TRCP1_1	0.7133
p.H885R	DO14270	HNSC	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	0.7133
p.P892L	TCGA-DU-6392	LGG	TCGA	DSGHAPS	DEG_SCF_TRCP1_1	0.2222
p.P892L	DO22237	LGG	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	0.2222
p.Q889E	TCGA-FU-A3TX	CESC	TCGA	DSGHAPS	DEG_SCF_TRCP1_1	0.3056
p.Q889E	DO44281	CESC	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	0.3056
p.G880R	DO229054	LICA	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	0.2778
p.R894M	DO46394	OV	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	0.1667
p.D882Y	SIDM00783	Colorectal Carcinoma	GDSC	DSGHAPS	DEG_SCF_TRCP1_1	0.7325
p.D882Y	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGHAPS	DEG_SCF_TRCP1_1	0.7325
p.D882Y	HCT-116	large_intestine	COSMIC	DSGHAPS	DEG_SCF_TRCP1_1	0.7325
p.A886T	ACH-000939	Sarcoma	CCLE	DSGHAPS	DEG_SCF_TRCP1_1	0.6028
p.A886T	SK-UT-1	soft_tissue	COSMIC	DSGHAPS	DEG_SCF_TRCP1_1	0.6028
p.S895A	ACH-002254	Lymphoma	CCLE	DSGHAPS	DEG_SCF_TRCP1_1	0.1389
p.S895A	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHAPS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDI7	Transmembrane channel-like protein 2	DEG_SCF_TRCP1_1	882:888	DSGHAPS	BTRC	0.9597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons