DegronMD

Uniprot ID: Q9UQB8

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2

Source gene: BAIAP2

Class: DEG_SCF_FBW7_1

Location: 347:352

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 91.1667

COIL: 0.9185

CONS_SCORE: 0.3354

DSS_SCORE: 0.5822

HELIX: 0.0405

FCONS_SCORE: 0.8157

RIG_SCORE: 0.6649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P342H	TCGA-AB-2883	LAML	TCGA	VTPKNS	DEG_SCF_FBW7_1	0.1944
p.P342L	TCGA-DD-AACP	LIHC	TCGA	VTPKNS	DEG_SCF_FBW7_1	0.1944
p.K344N	DO3110	BRCA	ICGC	VTPKNS	DEG_SCF_FBW7_1	0.25
p.K344T	DO43186	UCEC	ICGC	VTPKNS	DEG_SCF_FBW7_1	0.25
p.K359R	SIDM00698	Small Cell Lung Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	0.5833
p.K359R	NCI-H146	lung	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.5833
p.R344G	SIDM00789	Colorectal Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	0.25
p.R344G	HCT-15	large_intestine	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.25
p.S352G	SIDM01045	Endometrial Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	0.8104
p.S352G	EN	endometrium	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.8104
p.T356I	SIDM00217	Colorectal Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	0.6667
p.T356I	SNU-1040	large_intestine	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.6667
p.L361M	ACH-000669	Lung Cancer	CCLE	VTPKNS	DEG_SCF_FBW7_1	0.0833
p.S355G	ACH-000988	Endometrial/Uterine Cancer	CCLE	VTPKNS	DEG_SCF_FBW7_1	0.25
p.S355G	MFE-319	endometrium	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.25
p.S352R	NCI-H630	large_intestine	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.8538
p.Y343F	HMV-II	skin	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.2222
p.P360L	MONO-MAC-6	haematopoietic_and_lymphoid_tissue	COSMIC	VTPKNS	DEG_SCF_FBW7_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	DEG_SCF_FBW7_1	347:352	VTPKNS	FBXW7	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons