DegronMD - Q96RU8(TRIB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I347V	TCGA-A6-6781	COAD	TCGA	TSDQIVPEY	DEG_COP1_1	353:361	Mutation rewiring degron network	0.1667
p.Q356H	TCGA-AG-A002	READ	TCGA	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.647
p.P344S	TCGA-B5-A3FC	UCEC	TCGA	TSDQIVPEY	DEG_COP1_1	353:361	Mutation rewiring degron network	0.0833
p.F370S	TCGA-BF-A1Q0	SKCM	TCGA	TSDQIVPEY	DEG_COP1_1	353:361	Mutation rewiring degron network	0.0833
p.E360K	TCGA-C9-A47Z	HNSC	TCGA	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.7022
p.V46I	DO222973	BTCA	ICGC	PPDY	ITCH	56:59	Mutation blocking ubiquitination signal	0.5
p.V46I	DO41199	UCEC	ICGC	PPDY	ITCH	56:59	Mutation blocking ubiquitination signal	0.5
p.R66Q	DO222680	ESCA	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.V48L	DO233272	GACA	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1111
p.C47Y	DO14250	HNSC	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.0833
p.E52D	DO229032	LICA	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.2222
p.D55Y	DO229037	LICA	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.3056
p.R66W	DO35140	PACA	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.R66W	DO43041	UCEC	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.S65L	DO52155	PAEN	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1667
p.V48A	DO48020	STAD	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1111
p.T63A	DO42280	UCEC	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.2222
p.R67H	DO41109	UCEC	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1111
p.D62H	DO42633	UCEC	ICGC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.25
p.D62H	ACH-001786	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.25
p.D366V	SIDM01307	Colorectal Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation rewiring degron network	0.1944
p.E360D	SIDM00773	Non-Cancerous	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00969	Ovarian Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM01039	Other Solid Cancers	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00875	Breast Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00907	Burkitt's Lymphoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM01133	Other Solid Cancers	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00257	Neuroblastoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00720	Mesothelioma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM00808	Burkitt's Lymphoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM01664	Prostate Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.E360D	SIDM01254	Burkitt's Lymphoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation altering degron motif	0.5647
p.I367V	SIDM00472	Ovarian Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation rewiring degron network	0.1667
p.I367V	PEO1	ovary	COSMIC	TSDQIVPEY	DEG_COP1_1	353:361	Mutation rewiring degron network	0.1667
p.Q69E	ACH-000069	Lymphoma	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.0556
p.P62T	ACH-000342	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.25
p.Y51N	ACH-000660	Lymphoma	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1944
p.Y51N	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1944
p.T53N	ACH-000725	Breast Cancer	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.25
p.M66I	ACH-000732	Head and Neck Cancer	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.P62S	ACH-000763	Myeloma	CCLE	PPDY	ITCH	56:59	Mutation rewiring degron network	0.25

Kaplan plot for TRIB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIB1

UniProt ID: Q96RU8

Entrez ID: 10221

Protein name: Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIB1 in