DegronMD

Uniprot ID: Q96RU8

Source protein: Tribbles homolog 1

Source gene: TRIB1

Class: DEG_COP1_1

Location: 353:361

E3 ligase: COP1

DEGRON score: 0.989

ASA_SCORE: 86.4

COIL: 0.7786

CONS_SCORE: 0.7219

DSS_SCORE: 0.5155

HELIX: 0.1438

FCONS_SCORE: 1.5786

RIG_SCORE: 0.7916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I347V	TCGA-A6-6781	COAD	TCGA	TSDQIVPEY	DEG_COP1_1	0.1667
p.Q356H	TCGA-AG-A002	READ	TCGA	TSDQIVPEY	DEG_COP1_1	0.647
p.P344S	TCGA-B5-A3FC	UCEC	TCGA	TSDQIVPEY	DEG_COP1_1	0.0833
p.F370S	TCGA-BF-A1Q0	SKCM	TCGA	TSDQIVPEY	DEG_COP1_1	0.0833
p.E360K	TCGA-C9-A47Z	HNSC	TCGA	TSDQIVPEY	DEG_COP1_1	0.7022
p.D366V	SIDM01307	Colorectal Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.1944
p.E360D	SIDM00773	Non-Cancerous	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00969	Ovarian Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM01039	Other Solid Cancers	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00875	Breast Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00907	Burkitt's Lymphoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM01133	Other Solid Cancers	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00257	Neuroblastoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00720	Mesothelioma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM00808	Burkitt's Lymphoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM01664	Prostate Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.E360D	SIDM01254	Burkitt's Lymphoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.5647
p.I367V	SIDM00472	Ovarian Carcinoma	GDSC	TSDQIVPEY	DEG_COP1_1	0.1667
p.I367V	PEO1	ovary	COSMIC	TSDQIVPEY	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons