DegronMD

Uniprot ID: Q96JB1

Source protein: Dynein axonemal heavy chain 8

Source gene: DNAH8

Class: ITCH

Location: 4233:4236

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9067

ASA_SCORE: 68.55

COIL: 0.951

CONS_SCORE: 0.4968

DSS_SCORE: 0.3473

HELIX: 0.0385

FCONS_SCORE: 1.1617

RIG_SCORE: 0.7501

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4240D	TCGA-17-Z045	LUAD	TCGA	PPDY	ITCH	0.2222
p.E4226A	TCGA-AG-3725	READ	TCGA	PPDY	ITCH	0.1389
p.E4240K	TCGA-D3-A8GO	SKCM	TCGA	PPDY	ITCH	0.2222
p.E4226K	TCGA-E6-A1M0	UCEC	TCGA	PPDY	ITCH	0.1389
p.E4226K	DO220877	MELA	ICGC	PPDY	ITCH	0.1389
p.E4226K	DO43682	UCEC	ICGC	PPDY	ITCH	0.1389
p.S4243Y	TCGA-EO-A22X	UCEC	TCGA	PPDY	ITCH	0.1389
p.R4228T	DO8946	COAD	ICGC	PPDY	ITCH	0.1944
p.R4237C	DO229480	LAML	ICGC	PPDY	ITCH	0.3056
p.S4241I	DO229028	LICA	ICGC	PPDY	ITCH	0.1944
p.E4225K	DO229050	LICA	ICGC	PPDY	ITCH	0.1111
p.R4228G	DO51193	LUAD	ICGC	PPDY	ITCH	0.1944
p.I4235V	DO230990	LUSC	ICGC	PPDY	ITCH	0.7076
p.I4235V	DO231007	LUSC	ICGC	PPDY	ITCH	0.7076
p.I4235T	DO26862	LUSC	ICGC	PPDY	ITCH	0.7078
p.R4228K	DO219165	LUSC	ICGC	PPDY	ITCH	0.1944
p.R4228K	DO223910	SKCM	ICGC	PPDY	ITCH	0.1944
p.S4234L	DO222702	MELA	ICGC	PPDY	ITCH	0.7667
p.Q4224H	DO223286	UCEC	ICGC	PPDY	ITCH	0.0833
p.A4241T	SIDM00212	Glioblastoma	GDSC	PPDY	ITCH	0.1944
p.A4241T	SIDM01107	Melanoma	GDSC	PPDY	ITCH	0.1944
p.A4241T	SK-MEL-1	skin	COSMIC	PPDY	ITCH	0.1944
p.A4241T	CAS-1	central_nervous_system	COSMIC	PPDY	ITCH	0.1944
p.P4234S	ACH-000309	Lung Cancer	CCLE	PPDY	ITCH	0.6752
p.P4234S	SK-LU-1	lung	COSMIC	PPDY	ITCH	0.6752
p.L4229M	ACH-000869	Lung Cancer	CCLE	PPDY	ITCH	0.2222
p.L4229M	NCI-H1568	lung	COSMIC	PPDY	ITCH	0.2222

Drug responses associated with DNAH8 mutations

All proteins holding degron of PPDY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	ITCH	1299:1302	PPDY	ITCH,NEDD4	0.9707	More...
O15391	Transcription factor YY2	ITCH	207:210	PPDY	ITCH,NEDD4	0.9848	More...
O43390	Heterogeneous nuclear ribonucleoprotein R	ITCH	461:464	PPDY	ITCH,NEDD4	0.6735	More...
O43613	Orexin/Hypocretin receptor type 1	ITCH	24:27	PPDY	ITCH,NEDD4	0.7599	More...
O95985	DNA topoisomerase 3-beta-1	ITCH	490:493	PPDY	ITCH,NEDD4	0.8044	More...
P08151	Zinc finger protein GLI1	ITCH	869:872	PPDY	ITCH,NEDD4	0.9674	More...
P11686	Pulmonary surfactant-associated protein C	ITCH	13:16	PPDY	ITCH,NEDD4	0.5827	More...
P12956	X-ray repair cross-complementing protein 6	ITCH	531:534	PPDY	ITCH,NEDD4	0.9776	More...
P17568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	ITCH	26:29	PPDY	ITCH,NEDD4	0.9726	More...
P17948	Vascular endothelial growth factor receptor 1	ITCH	1324:1327	PPDY	ITCH,NEDD4	0.9853	More...
P20810	Calpastatin	ITCH	478:481	PPDY	ITCH,NEDD4	0.9995	More...
P25490	Transcriptional repressor protein YY1	ITCH	248:251	PPDY	ITCH,NEDD4	0.9971	More...
P61296	Heart- and neural crest derivatives-expressed protein 2	ITCH	55:58	PPDY	ITCH,NEDD4	0.829	More...
Q13405	39S ribosomal protein L49, mitochondrial	ITCH	32:35	PPDY	ITCH,NEDD4	0.9394	More...
Q15413	Ryanodine receptor 3	ITCH	2574:2577	PPDY	ITCH,NEDD4	0.5283	More...
Q4L180	Filamin A-interacting protein 1-like	ITCH	809:812	PPDY	ITCH,NEDD4	0.861	More...
Q5T442	Gap junction gamma-2 protein	ITCH	330:333	PPDY	ITCH,NEDD4	0.9661	More...
Q6UWN5	Ly6/PLAUR domain-containing protein 5	ITCH	94:97	PPDY	ITCH,NEDD4	0.7174	More...
Q6ZR08	Dynein axonemal heavy chain 12	ITCH	78:81	PPDY	ITCH,NEDD4	0.9568	More...
Q86VP1	Tax1-binding protein 1	ITCH	765:768	PPDY	ITCH,NEDD4	0.8675	More...
Q8IUY3	GRAM domain-containing protein 2A	ITCH	41:44	PPDY	ITCH,NEDD4	0.9404	More...
Q8IZL2	Mastermind-like protein 2	ITCH	127:130	PPDY	ITCH,NEDD4	0.9403	More...
Q8IZL2	Mastermind-like protein 2	ITCH	798:801	PPDY	ITCH,NEDD4	0.8792	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	ITCH	282:285	PPDY	ITCH,NEDD4	0.8863	More...
Q8N0W4	Neuroligin-4, X-linked	ITCH	757:760	PPDY	ITCH,NEDD4	0.9948	More...
Q8N2Q7	Neuroligin-1	ITCH	799:802	PPDY	ITCH,NEDD4	0.9681	More...
Q8N7E2	E3 ubiquitin-protein ligase CBLL2	ITCH	256:259	PPDY	ITCH,NEDD4	0.9915	More...
Q8NFZ3	Neuroligin-4, Y-linked	ITCH	757:760	PPDY	ITCH,NEDD4	0.9578	More...
Q8NFZ4	Neuroligin-2	ITCH	766:769	PPDY	ITCH,NEDD4	0.9784	More...
Q8TE73	Dynein axonemal heavy chain 5	ITCH	4368:4371	PPDY	ITCH,NEDD4	0.9769	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	ITCH	1529:1532	PPDY	ITCH,NEDD4	0.9998	More...
Q8WY41	Nanos homolog 1	ITCH	102:105	PPDY	ITCH,NEDD4	0.9214	More...
Q96I24	Far upstream element-binding protein 3	ITCH	540:543	PPDY	ITCH,NEDD4	0.995	More...
Q96JB1	Dynein axonemal heavy chain 8	ITCH	4233:4236	PPDY	ITCH,NEDD4	0.9067	More...
Q96KP6	TNFAIP3-interacting protein 3	ITCH	295:298	PPDY	ITCH,NEDD4	0.9842	More...
Q96RU8	Tribbles homolog 1	ITCH	56:59	PPDY	ITCH,NEDD4	0.9829	More...
Q9BTU6	Phosphatidylinositol 4-kinase type 2-alpha	ITCH	15:18	PPDY	ITCH,NEDD4	0.9952	More...
Q9P2J2	Protein turtle homolog A	ITCH	952:955	PPDY	ITCH,NEDD4	0.9985	More...
Q9UBS8	E3 ubiquitin-protein ligase RNF14	ITCH	80:83	PPDY	ITCH,NEDD4	0.791	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	ITCH	436:439	PPDY	ITCH,NEDD4	0.9989	More...
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	ITCH	1315:1318	PPDY	ITCH,NEDD4	0.9345	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	ITCH	468:471	PPDY	ITCH,NEDD4	0.9965	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	ITCH	956:959	PPDY	ITCH,NEDD4	0.9563	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	ITCH	1425:1428	PPDY	ITCH,NEDD4	0.99	More...
O15417	Trinucleotide repeat-containing gene 18 protein	ITCH	2281:2284	PPDY	ITCH,NEDD4	0.9571	More...
Q8NF86	Serine protease 33	ITCH	115:118	PPDY	ITCH,NEDD4	0.9376	More...
Q93075	Putative deoxyribonuclease TATDN2	ITCH	647:650	PPDY	ITCH,NEDD4	0.8378	More...
Q5SQS7	SH2 domain-containing protein 4B	ITCH	423:426	PPDY	ITCH,NEDD4	0.9123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPDY

Degron related mutations and impact score

Drug responses associated with DNAH8 mutations

All proteins holding degron of PPDY