DegronMD - Q86VP1(TAX1BP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F746I	TCGA-A3-3357	KIRC	TCGA	PPNY	ITCH	738:741	Mutation rewiring degron network	0.1944
p.S744I	TCGA-AX-A06F	UCEC	TCGA	PPNY	ITCH	738:741	Mutation rewiring degron network	0.25
p.E692D	TCGA-AX-A2HC	UCEC	TCGA	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.5647
p.N699D	TCGA-AZ-4615	COAD	TCGA	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.5821
p.N699D	TCGA-B5-A3FA	UCEC	TCGA	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.5821
p.R712H	TCGA-B5-A3FC	UCEC	TCGA	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.0833
p.H749Y	TCGA-DF-A2KU	UCEC	TCGA	PPNY	ITCH	738:741	Mutation rewiring degron network	0.1111
p.V756L	TCGA-FW-A3TU	SKCM	TCGA	PPDY	ITCH	765:768	Mutation rewiring degron network	0.0833
p.E762K	TCGA-VS-A9U5	CESC	TCGA	PPDY	ITCH	765:768	Mutation rewiring degron network	0.25
p.E774Q	TCGA-XF-A9T8	BLCA	TCGA	PPDY	ITCH	765:768	Mutation rewiring degron network	0.1667
p.E732Q	DO51927	BLCA	ICGC	PPNY	ITCH	738:741	Mutation rewiring degron network	0.1667
p.F704I	DO20396	KIRC	ICGC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.3056
p.K713N	DO229015	LICA	ICGC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.0556
p.H707Y	DO223286	UCEC	ICGC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.2222
p.S702I	DO41752	UCEC	ICGC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.7341
p.T702A	SIDM01245	T-Lymphoblastic Leukemia	GDSC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.7139
p.T702A	SIDM00991	T-Lymphoblastic Leukemia	GDSC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.7139
p.T702A	BE-13	haematopoietic and lymphoid tissue	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.7139
p.L688S	SIDM00238	Ovarian Carcinoma	GDSC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.25
p.L688S	ACH-000947	Ovarian Cancer	CCLE	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.25
p.L688S	OVK-18	ovary	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.25
p.F737I	SIDM00282	Colorectal Carcinoma	GDSC	PPNY	ITCH	738:741	Mutation rewiring degron network	0.3056
p.F737I	ACH-000998	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	738:741	Mutation rewiring degron network	0.3056
p.F737I	CW-2	large intestine	COSMIC	PPNY	ITCH	738:741	Mutation rewiring degron network	0.3056
p.P766S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PPDY	ITCH	765:768	Mutation altering degron motif	0.6752
p.P766S	ACH-000837	Lung Cancer	CCLE	PPDY	ITCH	765:768	Mutation altering degron motif	0.6752
p.P766S	NCI-H322M	lung	COSMIC	PPDY	ITCH	765:768	Mutation altering degron motif	0.6752
p.R684Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.1389
p.R684Q	ACH-000782	Leukemia	CCLE	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.1389
p.R684Q	ACH-001735	Leukemia	CCLE	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.1389
p.N699S	ACH-000966	Ovarian Cancer	CCLE	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.5958
p.V743I	BFTC-909	kidney	COSMIC	PPNY	ITCH	738:741	Mutation rewiring degron network	0.2778
p.V743I	BFTC-905	urinary tract	COSMIC	PPNY	ITCH	738:741	Mutation rewiring degron network	0.2778
p.F695I	CW-2	large intestine	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.7415
p.G692V	NCI-H522	lung	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation altering degron motif	0.7532
p.N745T	HCC2998	large intestine	COSMIC	PPNY	ITCH	738:741	Mutation substituting flanking lysine	0.3333
p.F761I	CW-2	large intestine	COSMIC	PPDY	ITCH	765:768	Mutation rewiring degron network	0.2222
p.L712S	OVK-18	ovary	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	691:703	Mutation rewiring degron network	0.0833

Kaplan plot for TAX1BP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAX1BP1

UniProt ID: Q86VP1

Entrez ID: 8887

Protein name: Tax1-binding protein 1 (TRAF6-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAX1BP1 in