DegronMD

Uniprot ID: Q86VP1

Source protein: Tax1-binding protein 1

Source gene: TAX1BP1

Class: DEG_COP1_1

Location: 691:703

E3 ligase: COP1

DEGRON score: 0.7654

ASA_SCORE: 97.4077

COIL: 0.8574

CONS_SCORE: 0.8495

DSS_SCORE: 0.817

HELIX: 0.1292

FCONS_SCORE: 0.9951

RIG_SCORE: 0.6018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E692D	TCGA-AX-A2HC	UCEC	TCGA	SEDSKEDENVPTA	DEG_COP1_1	0.5647
p.N699D	TCGA-AZ-4615	COAD	TCGA	SEDSKEDENVPTA	DEG_COP1_1	0.5821
p.N699D	TCGA-B5-A3FA	UCEC	TCGA	SEDSKEDENVPTA	DEG_COP1_1	0.5821
p.R712H	TCGA-B5-A3FC	UCEC	TCGA	SEDSKEDENVPTA	DEG_COP1_1	0.0833
p.F704I	DO20396	KIRC	ICGC	SEDSKEDENVPTA	DEG_COP1_1	0.3056
p.K713N	DO229015	LICA	ICGC	SEDSKEDENVPTA	DEG_COP1_1	0.0556
p.H707Y	DO223286	UCEC	ICGC	SEDSKEDENVPTA	DEG_COP1_1	0.2222
p.S702I	DO41752	UCEC	ICGC	SEDSKEDENVPTA	DEG_COP1_1	0.7341
p.T702A	SIDM01245	T-Lymphoblastic Leukemia	GDSC	SEDSKEDENVPTA	DEG_COP1_1	0.7139
p.T702A	SIDM00991	T-Lymphoblastic Leukemia	GDSC	SEDSKEDENVPTA	DEG_COP1_1	0.7139
p.T702A	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	0.7139
p.L688S	SIDM00238	Ovarian Carcinoma	GDSC	SEDSKEDENVPTA	DEG_COP1_1	0.25
p.L688S	ACH-000947	Ovarian Cancer	CCLE	SEDSKEDENVPTA	DEG_COP1_1	0.25
p.L688S	OVK-18	ovary	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	0.25
p.R684Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	SEDSKEDENVPTA	DEG_COP1_1	0.1389
p.R684Q	ACH-000782	Leukemia	CCLE	SEDSKEDENVPTA	DEG_COP1_1	0.1389
p.R684Q	ACH-001735	Leukemia	CCLE	SEDSKEDENVPTA	DEG_COP1_1	0.1389
p.N699S	ACH-000966	Ovarian Cancer	CCLE	SEDSKEDENVPTA	DEG_COP1_1	0.5958
p.F695I	CW-2	large_intestine	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	0.7415
p.G692V	NCI-H522	lung	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	0.7532
p.L712S	OVK-18	ovary	COSMIC	SEDSKEDENVPTA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VP1	Tax1-binding protein 1	DEG_COP1_1	691:703	SEDSKEDENVPTA	COP1	0.7654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons