DegronMD - Q6ZR08(DNAH12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P79H	TCGA-18-3412	LUSC	TCGA	PPDY	ITCH	78:81	Mutation altering degron motif	0.7694
p.P79H	DO26552	LUSC	ICGC	PPDY	ITCH	78:81	Mutation altering degron motif	0.7694
p.R85Q	TCGA-A5-A3LP	UCEC	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.2222
p.I82V	TCGA-A6-6780	COAD	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.R88I	TCGA-AA-3984	COAD	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.1389
p.P37S	TCGA-AA-A010	COAD	TCGA	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.6752
p.L84I	TCGA-AJ-A5DW	UCEC	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.25
p.L84I	TCGA-AX-A0J0	UCEC	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.25
p.L84I	TCGA-BS-A0UV	UCEC	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.25
p.Q79H	TCGA-AZ-4315	COAD	TCGA	PPDY	ITCH	78:81	Mutation altering degron motif	0.7582
p.P22L	TCGA-B5-A1MX	UCEC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0556
p.P22L	DO41999	UCEC	ICGC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0556
p.K73N	TCGA-BS-A0UF	UCEC	TCGA	PPDY	ITCH	78:81	Mutation blocking phosphorylation signal	0.6389
p.K73N	TCGA-F5-6814	READ	TCGA	PPDY	ITCH	78:81	Mutation blocking phosphorylation signal	0.6389
p.L48M	TCGA-BS-A0UV	UCEC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0556
p.C43S	TCGA-C5-A8XH	CESC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1944
p.Q83E	TCGA-E7-A7DV	BLCA	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.2778
p.Q83E	DO48583	BLCA	ICGC	PPDY	ITCH	78:81	Mutation rewiring degron network	0.2778
p.L46I	TCGA-EO-A3AV	UCEC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1111
p.M89I	TCGA-FS-A1ZS	SKCM	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.M89I	DO37806	SKCM	ICGC	PPDY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.F38V	TCGA-OY-A56P	OV	TCGA	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.7068
p.G70S	TCGA-VQ-A8PT	STAD	TCGA	PPDY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.G70S	DO51776	STAD	ICGC	PPDY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.N29K	DO225360	BRCA	ICGC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.25
p.E28K	DO234398	ESAD	ICGC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2222
p.V32A	DO234285	ESAD	ICGC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.6936
p.V32A	DO231049	LUSC	ICGC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.6936
p.Q83K	DO229027	LICA	ICGC	PPDY	ITCH	78:81	Mutation rewiring degron network	0.2778
p.Q37K	DO229031	LICA	ICGC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.5833
p.T86N	DO229038	LICA	ICGC	PPDY	ITCH	78:81	Mutation rewiring degron network	0.1944
p.L41V	SIDM00040	Gastric Carcinoma	GDSC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.25
p.L41V	ACH-002202	Gastric Cancer	CCLE	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.25
p.L41V	TMK-1	stomach	COSMIC	VDTPTQS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.25
p.Y81C	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PPDY	ITCH	78:81	Mutation altering degron motif	0.8198
p.Y81C	BALL-1	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	78:81	Mutation altering degron motif	0.8198

Kaplan plot for DNAH12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH12

UniProt ID: Q6ZR08

Entrez ID: 201625

Protein name: Dynein axonemal heavy chain 12 (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein axonemal heavy chain 7-like) (Dynein heavy chain domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH12 in