DegronMD

Uniprot ID: Q6ZR08

Source protein: Dynein axonemal heavy chain 12

Source gene: DNAH12

Class: DEG_SCF_FBW7_1

Location: 32:38

E3 ligase: FBXW7

DEGRON score: 0.9778

ASA_SCORE: 73.8429

COIL: 0.8169

CONS_SCORE: 0.2476

DSS_SCORE: 0.4188

HELIX: 0.1557

FCONS_SCORE: 1.0055

RIG_SCORE: 0.7506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P37S	TCGA-AA-A010	COAD	TCGA	VDTPTQS	DEG_SCF_FBW7_1	0.6752
p.P22L	TCGA-B5-A1MX	UCEC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	0.0556
p.P22L	DO41999	UCEC	ICGC	VDTPTQS	DEG_SCF_FBW7_1	0.0556
p.L48M	TCGA-BS-A0UV	UCEC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	0.0556
p.C43S	TCGA-C5-A8XH	CESC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	0.1944
p.L46I	TCGA-EO-A3AV	UCEC	TCGA	VDTPTQS	DEG_SCF_FBW7_1	0.1111
p.F38V	TCGA-OY-A56P	OV	TCGA	VDTPTQS	DEG_SCF_FBW7_1	0.7068
p.N29K	DO225360	BRCA	ICGC	VDTPTQS	DEG_SCF_FBW7_1	0.25
p.E28K	DO234398	ESAD	ICGC	VDTPTQS	DEG_SCF_FBW7_1	0.2222
p.V32A	DO234285	ESAD	ICGC	VDTPTQS	DEG_SCF_FBW7_1	0.6936
p.V32A	DO231049	LUSC	ICGC	VDTPTQS	DEG_SCF_FBW7_1	0.6936
p.Q37K	DO229031	LICA	ICGC	VDTPTQS	DEG_SCF_FBW7_1	0.5833
p.L41V	SIDM00040	Gastric Carcinoma	GDSC	VDTPTQS	DEG_SCF_FBW7_1	0.25
p.L41V	ACH-002202	Gastric Cancer	CCLE	VDTPTQS	DEG_SCF_FBW7_1	0.25
p.L41V	TMK-1	stomach	COSMIC	VDTPTQS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZR08	Dynein axonemal heavy chain 12	DEG_SCF_FBW7_1	32:38	VDTPTQS	FBXW7	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons