DegronMD - Q9UPX8(SHANK2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1328S	TCGA-17-Z031	LUAD	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.0556
p.R959P	TCGA-28-1757	GBM	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2222
p.R959P	DO12166	GBM	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2222
p.Q1309K	TCGA-28-1760	GBM	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1667
p.Q1309K	DO13725	GBM	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1667
p.S811L	TCGA-37-4130	LUSC	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.7667
p.S811L	DO26490	LUSC	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.7667
p.R805L	TCGA-91-8497	LUAD	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.8428
p.R805L	DO45325	LUAD	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.8428
p.E818K	TCGA-A5-A2K5	UCEC	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.E818K	TCGA-ER-A193	SKCM	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.E818K	DO47368	SKCM	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.E818K	DO41379	UCEC	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.R740W	TCGA-AA-A022	COAD	TCGA	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.25
p.R740W	DO10647	COAD	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.25
p.E652K	TCGA-AC-A23H	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.E652K	TCGA-D6-6516	HNSC	TCGA	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.E652K	DO2401	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.E652K	DO15623	HNSC	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.A662V	TCGA-AP-A1DK	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.6936
p.A662V	TCGA-D3-A8GI	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.6936
p.A662V	DO50284	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.6936
p.A662V	DO42033	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.6936
p.S1311L	TCGA-AX-A2HD	UCEC	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.S1311L	TCGA-QG-A5YV	COAD	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.S1311L	DO44088	COAD	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.S1311L	DO42608	UCEC	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.T1323S	TCGA-B0-5107	KIRC	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1944
p.T1323S	DO20426	KIRC	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1944
p.R801L	TCGA-B5-A0JZ	UCEC	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.R801L	DO42761	UCEC	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.R749C	TCGA-B5-A11E	UCEC	TCGA	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation altering degron motif	0.8301
p.R749C	DO41644	UCEC	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation altering degron motif	0.8301
p.R959C	TCGA-B5-A3FA	UCEC	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2222
p.R959C	DO52402	UCEC	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2222
p.F978V	TCGA-BA-6868	HNSC	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1944
p.F978V	DO14184	HNSC	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1944
p.A796V	TCGA-BR-8078	STAD	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1111
p.A796V	DO228138	PBCA	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1111
p.A796V	DO38288	STAD	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1111
p.A796V	SIDM00783	Colorectal Carcinoma	GDSC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1111
p.A796V	HCT-116	large intestine	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1111
p.S1307T	TCGA-CD-A4MI	STAD	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.S1307T	DO47717	STAD	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.R819C	TCGA-CM-5860	COAD	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1389
p.R819C	DO10542	COAD	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1389
p.E667K	TCGA-D3-A2JD	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation substituting flanking lysine	0.3611
p.E667K	DO37543	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation substituting flanking lysine	0.3611
p.F660S	TCGA-D7-5579	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7982
p.F660S	DO38571	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7982
p.M813I	TCGA-E2-A1AZ	BRCA	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation blocking phosphorylation signal	0.75
p.M813I	DO1727	BRCA	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation blocking phosphorylation signal	0.75
p.M813I	DO46342	OV	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation blocking phosphorylation signal	0.75
p.T747A	TCGA-E6-A2P9	UCEC	TCGA	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation altering degron motif	0.7139
p.T747A	DO43714	UCEC	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation altering degron motif	0.7139
p.R801Q	TCGA-E9-A6HE	BRCA	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.R801Q	DO50048	BRCA	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.R979C	TCGA-EB-A5UN	SKCM	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.R979C	TCGA-EE-A2MR	SKCM	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.R979C	DO47267	SKCM	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.R979C	DO37819	SKCM	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.S1307F	TCGA-EE-A3J7	SKCM	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.S1307F	TCGA-YG-AA3N	SKCM	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.S1307F	DO229446	SKCA	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.S1307F	DO48770	SKCM	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.S1307F	DO51298	SKCM	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.A976S	TCGA-EI-6507	READ	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.25
p.A976S	DO36675	READ	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.25
p.A1322T	TCGA-FF-A7CQ	DLBC	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.A1322T	DO219893	DLBC	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.A1322T	DO233748	GACA	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.2222
p.S961F	TCGA-FS-A1ZK	SKCM	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2778
p.S961F	DO37474	SKCM	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2778
p.S815F	TCGA-FS-A1ZK	SKCM	TCGA	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.S815F	DO37474	SKCM	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.T1319A	TCGA-HU-A4G9	STAD	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.3056
p.T1319A	DO47789	STAD	ICGC	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.3056
p.D1326H	TCGA-IG-A5B8	ESCA	TCGA	PPDY	ITCH	1315:1318	Mutation rewiring degron network	0.1111
p.R979H	TCGA-XK-AAIW	PRAD	TCGA	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.R979H	DO51407	PRAD	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.R819H	DO222461	BTCA	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1389
p.S476F	DO50384	ESAD	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation altering degron motif	0.7982
p.S476F	DO228988	LICA	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation altering degron motif	0.7982
p.L511P	DO234353	ESAD	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation rewiring degron network	0.0556
p.R475W	DO223018	ESCA	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation altering degron motif	0.8634
p.P661Q	DO223046	ESCA	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7035
p.L495V	DO223051	ESCA	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation altering degron motif	0.6765
p.Y968F	DO228202	LICA	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation altering degron motif	0.7528
p.Q664H	DO228828	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7582
p.R959S	DO228952	LICA	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.2222
p.T657K	DO228974	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.25
p.L957M	DO229022	LICA	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.1667
p.R473S	DO23608	LUAD	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation altering degron motif	0.7427
p.Y968C	DO230550	LUSC	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation altering degron motif	0.7087
p.S752F	DO231127	LUSC	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.25
p.S752F	DO37531	SKCM	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.25
p.S815C	DO220891	MELA	ICGC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.25
p.K733I	DO222599	MELA	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.0556
p.P658L	DO222731	MELA	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.P658L	DO50420	PRAD	ICGC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.N507S	DO27891	ORCA	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation rewiring degron network	0.1667
p.H497N	DO52124	PAEN	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation altering degron motif	0.7423
p.N971D	DO35553	PBCA	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation altering degron motif	0.6932
p.R749H	DO232224	PBCA	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation altering degron motif	0.8244
p.R955G	DO51964	PRAD	ICGC	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation substituting flanking lysine	0.2222
p.P738L	DO37409	SKCM	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.1944
p.P492L	DO38404	STAD	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation altering degron motif	0.7582
p.E756D	DO229272	THCA	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.1389
p.G470R	SIDM02028	Esophageal Carcinoma	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation blocking phosphorylation signal	0.6944
p.P491S	SIDM00007	Other Solid Cancers	GDSC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation altering degron motif	0.5641
p.A492T	SIDM00202	Ewing's Sarcoma	GDSC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation altering degron motif	0.7139
p.A492T	EW-3	bone	COSMIC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation altering degron motif	0.7139
p.P472T	SIDM00329	Hodgkin's Lymphoma	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.3056
p.P472T	L-540	haematopoietic and lymphoid tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.3056
p.P469S	SIDM00002	Neuroblastoma	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation substituting flanking lysine	0.3333
p.P469S	NBsusSR	autonomic ganglia	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation substituting flanking lysine	0.3333
p.P807H	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.6583
p.P807H	KYSE-140	oesophagus	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.6583
p.S810F	SIDM00003	Melanoma	GDSC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.7982
p.S810F	M14	skin	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.7982
p.E742K	SIDM00140	Melanoma	GDSC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.3056
p.E742K	COLO-792	skin	COSMIC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.3056
p.R479W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation altering degron motif	0.8634
p.R479W	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation altering degron motif	0.8634
p.P806L	SIDM01608	Endometrial Carcinoma	GDSC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation altering degron motif	0.7582
p.P798H	ACH-000278	Ovarian Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.P798T	ACH-000278	Ovarian Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.D1317E	ACH-000308	Ovarian Cancer	CCLE	PPDY	ITCH	1315:1318	Mutation altering degron motif	0.5647
p.P464T	ACH-000806	Lymphoma	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.0833
p.P464T	L-540	haematopoietic and lymphoid tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.0833
p.S802F	ACH-000884	Skin Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.2778
p.S802F	ACH-002159	Skin Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.2778
p.S802F	M14	skin	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.2778
p.R471W	ACH-000918	Leukemia	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.2778
p.R471W	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.2778
p.R485W	ACH-000943	Colon/Colorectal Cancer	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.2222
p.R485W	ACH-000943	Colon/Colorectal Cancer	CCLE	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation rewiring degron network	0.25
p.E734K	ACH-000968	Skin Cancer	CCLE	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.0833
p.E734K	COLO-792	skin	COSMIC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation rewiring degron network	0.0833
p.P818L	ACH-000987	Skin Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.P818L	Mewo	skin	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.P798L	ACH-000990	Endometrial/Uterine Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.1667
p.D746H	ACH-001411	Bladder Cancer	CCLE	RPSMFPE	LIG_APCC_ABBAyCdc20_2	743:749	Mutation altering degron motif	0.7688
p.R674W	ACH-001737	Leukemia	CCLE	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0556
p.R674W	ACH-002222	Leukemia	CCLE	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0556
p.R674W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0556
p.A484T	ACH-002118	Bone Cancer	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.25
p.A484T	ACH-002118	Bone Cancer	CCLE	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation rewiring degron network	0.2222
p.A484T	EW-3	bone	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	473:481	Mutation rewiring degron network	0.25
p.A484T	EW-3	bone	COSMIC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation rewiring degron network	0.2222
p.P983L	ACH-002343	Non-Cancerous	CCLE	DSSPSEVPEGV	DEG_COP1_1	963:973	Mutation rewiring degron network	0.0556
p.E652D	CHL-1	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.R800Q	OE33	oesophagus	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.2222
p.A795V	SK-LU-1	lung	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation rewiring degron network	0.0833
p.D669N	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1944
p.P504L	LU-134-A	lung	COSMIC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	488:501	Mutation rewiring degron network	0.25
p.P799H	KYSE-140	oesophagus	COSMIC	ESSPAVPSA	DEG_COP1_1	804:812	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHANK2

UniProt ID: Q9UPX8

Entrez ID: 22941

Protein name: SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHANK2 in