DegronMD

Uniprot ID: Q9UPX8

Source protein: SH3 and multiple ankyrin repeat domains protein 2

Source gene: SHANK2

Class: DEG_APCC_DBOX_1

Location: 473:481

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9562

ASA_SCORE: 69.9111

COIL: 0.686

CONS_SCORE: 0.202

DSS_SCORE: 0.4243

HELIX: 0.2287

FCONS_SCORE: 0.637

RIG_SCORE: 0.7839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S476F	DO50384	ESAD	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	0.7982
p.S476F	DO228988	LICA	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	0.7982
p.R475W	DO223018	ESCA	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	0.8634
p.R473S	DO23608	LUAD	ICGC	SRIFLSGIT	DEG_APCC_DBOX_1	0.7427
p.G470R	SIDM02028	Esophageal Carcinoma	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	0.6944
p.P472T	SIDM00329	Hodgkin's Lymphoma	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	0.3056
p.P472T	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	0.3056
p.P469S	SIDM00002	Neuroblastoma	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	0.3333
p.P469S	NBsusSR	autonomic_ganglia	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	0.3333
p.R479W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SRIFLSGIT	DEG_APCC_DBOX_1	0.8634
p.R479W	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	0.8634
p.P464T	ACH-000806	Lymphoma	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	0.0833
p.P464T	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	0.0833
p.R471W	ACH-000918	Leukemia	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	0.2778
p.R471W	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	0.2778
p.R485W	ACH-000943	Colon/Colorectal Cancer	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	0.2222
p.A484T	ACH-002118	Bone Cancer	CCLE	SRIFLSGIT	DEG_APCC_DBOX_1	0.25
p.A484T	EW-3	bone	COSMIC	SRIFLSGIT	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	DEG_APCC_DBOX_1	473:481	SRIFLSGIT	APC,CDC20,FZR1	0.9562	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons