DegronMD

Uniprot ID: Q9UPX8

Source protein: SH3 and multiple ankyrin repeat domains protein 2

Source gene: SHANK2

Class: DEG_ODPH_VHL_1

Location: 488:501

E3 ligase: VHL

DEGRON score: 0.949

ASA_SCORE: 85.9429

COIL: 0.8726

CONS_SCORE: 0.3329

DSS_SCORE: 0.5673

HELIX: 0.0836

FCONS_SCORE: 1.1182

RIG_SCORE: 0.7151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L511P	DO234353	ESAD	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.0556
p.L495V	DO223051	ESCA	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.6765
p.N507S	DO27891	ORCA	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.1667
p.H497N	DO52124	PAEN	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.7423
p.P492L	DO38404	STAD	ICGC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.7582
p.P491S	SIDM00007	Other Solid Cancers	GDSC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.5641
p.A492T	SIDM00202	Ewing's Sarcoma	GDSC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.7139
p.A492T	EW-3	bone	COSMIC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.7139
p.R485W	ACH-000943	Colon/Colorectal Cancer	CCLE	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.25
p.A484T	ACH-002118	Bone Cancer	CCLE	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.2222
p.A484T	EW-3	bone	COSMIC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.2222
p.P504L	LU-134-A	lung	COSMIC	LAPPMLKFTRSLSM	DEG_ODPH_VHL_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	DEG_ODPH_VHL_1	488:501	LAPPMLKFTRSLSM	VHL	0.949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons