DegronMD

Uniprot ID: Q9UPX8

Source protein: SH3 and multiple ankyrin repeat domains protein 2

Source gene: SHANK2

Class: DEG_COP1_1

Location: 963:973

E3 ligase: COP1

DEGRON score: 0.8465

ASA_SCORE: 88.4818

COIL: 0.9612

CONS_SCORE: 0.2543

DSS_SCORE: 0.7582

HELIX: 0.0195

FCONS_SCORE: 0.9076

RIG_SCORE: 0.5749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R959P	TCGA-28-1757	GBM	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.2222
p.R959P	DO12166	GBM	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.2222
p.R959C	TCGA-B5-A3FA	UCEC	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.2222
p.R959C	DO52402	UCEC	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.2222
p.F978V	TCGA-BA-6868	HNSC	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.1944
p.F978V	DO14184	HNSC	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.1944
p.R979C	TCGA-EB-A5UN	SKCM	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.R979C	TCGA-EE-A2MR	SKCM	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.R979C	DO47267	SKCM	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.R979C	DO37819	SKCM	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.A976S	TCGA-EI-6507	READ	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.25
p.A976S	DO36675	READ	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.25
p.S961F	TCGA-FS-A1ZK	SKCM	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.2778
p.S961F	DO37474	SKCM	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.2778
p.R979H	TCGA-XK-AAIW	PRAD	TCGA	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.R979H	DO51407	PRAD	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.Y968F	DO228202	LICA	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.7528
p.R959S	DO228952	LICA	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.2222
p.L957M	DO229022	LICA	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.1667
p.Y968C	DO230550	LUSC	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.7087
p.N971D	DO35553	PBCA	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.6932
p.R955G	DO51964	PRAD	ICGC	DSSPSEVPEGV	DEG_COP1_1	0.2222
p.P983L	ACH-002343	Non-Cancerous	CCLE	DSSPSEVPEGV	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	DEG_COP1_1	963:973	DSSPSEVPEGV	COP1	0.8465	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons