DegronMD

Uniprot ID: Q9UPX8

Source protein: SH3 and multiple ankyrin repeat domains protein 2

Source gene: SHANK2

Class: DEG_COP1_1

Location: 804:812

E3 ligase: COP1

DEGRON score: 0.9941

ASA_SCORE: 89.0667

COIL: 0.9693

CONS_SCORE: 0.3051

DSS_SCORE: 0.7141

HELIX: 0.015

FCONS_SCORE: 1.0563

RIG_SCORE: 0.5457

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S811L	TCGA-37-4130	LUSC	TCGA	ESSPAVPSA	DEG_COP1_1	0.7667
p.S811L	DO26490	LUSC	ICGC	ESSPAVPSA	DEG_COP1_1	0.7667
p.R805L	TCGA-91-8497	LUAD	TCGA	ESSPAVPSA	DEG_COP1_1	0.8428
p.R805L	DO45325	LUAD	ICGC	ESSPAVPSA	DEG_COP1_1	0.8428
p.E818K	TCGA-A5-A2K5	UCEC	TCGA	ESSPAVPSA	DEG_COP1_1	0.1667
p.E818K	TCGA-ER-A193	SKCM	TCGA	ESSPAVPSA	DEG_COP1_1	0.1667
p.E818K	DO47368	SKCM	ICGC	ESSPAVPSA	DEG_COP1_1	0.1667
p.E818K	DO41379	UCEC	ICGC	ESSPAVPSA	DEG_COP1_1	0.1667
p.R801L	TCGA-B5-A0JZ	UCEC	TCGA	ESSPAVPSA	DEG_COP1_1	0.25
p.R801L	DO42761	UCEC	ICGC	ESSPAVPSA	DEG_COP1_1	0.25
p.A796V	TCGA-BR-8078	STAD	TCGA	ESSPAVPSA	DEG_COP1_1	0.1111
p.A796V	DO228138	PBCA	ICGC	ESSPAVPSA	DEG_COP1_1	0.1111
p.A796V	DO38288	STAD	ICGC	ESSPAVPSA	DEG_COP1_1	0.1111
p.A796V	SIDM00783	Colorectal Carcinoma	GDSC	ESSPAVPSA	DEG_COP1_1	0.1111
p.A796V	HCT-116	large_intestine	COSMIC	ESSPAVPSA	DEG_COP1_1	0.1111
p.R819C	TCGA-CM-5860	COAD	TCGA	ESSPAVPSA	DEG_COP1_1	0.1389
p.R819C	DO10542	COAD	ICGC	ESSPAVPSA	DEG_COP1_1	0.1389
p.M813I	TCGA-E2-A1AZ	BRCA	TCGA	ESSPAVPSA	DEG_COP1_1	0.75
p.M813I	DO1727	BRCA	ICGC	ESSPAVPSA	DEG_COP1_1	0.75
p.M813I	DO46342	OV	ICGC	ESSPAVPSA	DEG_COP1_1	0.75
p.R801Q	TCGA-E9-A6HE	BRCA	TCGA	ESSPAVPSA	DEG_COP1_1	0.25
p.R801Q	DO50048	BRCA	ICGC	ESSPAVPSA	DEG_COP1_1	0.25
p.S815F	TCGA-FS-A1ZK	SKCM	TCGA	ESSPAVPSA	DEG_COP1_1	0.25
p.S815F	DO37474	SKCM	ICGC	ESSPAVPSA	DEG_COP1_1	0.25
p.R819H	DO222461	BTCA	ICGC	ESSPAVPSA	DEG_COP1_1	0.1389
p.S815C	DO220891	MELA	ICGC	ESSPAVPSA	DEG_COP1_1	0.25
p.P807H	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	ESSPAVPSA	DEG_COP1_1	0.6583
p.P807H	KYSE-140	oesophagus	COSMIC	ESSPAVPSA	DEG_COP1_1	0.6583
p.S810F	SIDM00003	Melanoma	GDSC	ESSPAVPSA	DEG_COP1_1	0.7982
p.S810F	M14	skin	COSMIC	ESSPAVPSA	DEG_COP1_1	0.7982
p.P806L	SIDM01608	Endometrial Carcinoma	GDSC	ESSPAVPSA	DEG_COP1_1	0.7582
p.P798H	ACH-000278	Ovarian Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	0.1667
p.P798T	ACH-000278	Ovarian Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	0.1667
p.S802F	ACH-000884	Skin Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	0.2778
p.S802F	ACH-002159	Skin Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	0.2778
p.S802F	M14	skin	COSMIC	ESSPAVPSA	DEG_COP1_1	0.2778
p.P818L	ACH-000987	Skin Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	0.1667
p.P818L	Mewo	skin	COSMIC	ESSPAVPSA	DEG_COP1_1	0.1667
p.P798L	ACH-000990	Endometrial/Uterine Cancer	CCLE	ESSPAVPSA	DEG_COP1_1	0.1667
p.R800Q	OE33	oesophagus	COSMIC	ESSPAVPSA	DEG_COP1_1	0.2222
p.A795V	SK-LU-1	lung	COSMIC	ESSPAVPSA	DEG_COP1_1	0.0833
p.P799H	KYSE-140	oesophagus	COSMIC	ESSPAVPSA	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ESSPAVPSA

Degron related mutations and impact score

Drug responses associated with SHANK2 mutations

All proteins holding degron of ESSPAVPSA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	DEG_COP1_1	804:812	ESSPAVPSA	COP1	0.9941	More...