DegronMD

Uniprot ID: Q9UPX8

Source protein: SH3 and multiple ankyrin repeat domains protein 2

Source gene: SHANK2

Class: LIG_APCC_ABBAyCdc20_2

Location: 743:749

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9592

ASA_SCORE: 96.1143

COIL: 0.939

CONS_SCORE: 0.3702

DSS_SCORE: 0.801

HELIX: 0.03

FCONS_SCORE: 1.0933

RIG_SCORE: 0.6275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R740W	TCGA-AA-A022	COAD	TCGA	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.25
p.R740W	DO10647	COAD	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.25
p.R749C	TCGA-B5-A11E	UCEC	TCGA	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R749C	DO41644	UCEC	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.8301
p.T747A	TCGA-E6-A2P9	UCEC	TCGA	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.7139
p.T747A	DO43714	UCEC	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.7139
p.S752F	DO231127	LUSC	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.25
p.S752F	DO37531	SKCM	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.25
p.K733I	DO222599	MELA	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R749H	DO232224	PBCA	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.8244
p.P738L	DO37409	SKCM	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E756D	DO229272	THCA	ICGC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E742K	SIDM00140	Melanoma	GDSC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E742K	COLO-792	skin	COSMIC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E734K	ACH-000968	Skin Cancer	CCLE	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E734K	COLO-792	skin	COSMIC	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D746H	ACH-001411	Bladder Cancer	CCLE	RPSMFPE	LIG_APCC_ABBAyCdc20_2	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	LIG_APCC_ABBAyCdc20_2	743:749	RPSMFPE	APC,CDC20,FZR1	0.9592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons