DegronMD - Q15413(RYR3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A4177V	TCGA-06-5416	GBM	TCGA	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation rewiring degron network	0.1111
p.A4177V	DO10880	GBM	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation rewiring degron network	0.1111
p.V485F	TCGA-06-6388	GBM	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1389
p.V485F	DO14109	GBM	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1389
p.D337E	TCGA-17-Z062	LUAD	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.5647
p.K382T	TCGA-21-5787	LUSC	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.3056
p.K382T	DO26605	LUSC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.3056
p.N464K	TCGA-34-8455	LUSC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1111
p.N464K	DO50095	LUSC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1111
p.R467H	TCGA-51-6867	LUSC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1944
p.R467H	DO26477	LUSC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1944
p.S4186Y	TCGA-55-7724	LUAD	TCGA	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.6009
p.S4186Y	DO45373	LUAD	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.6009
p.S4186Y	SIDM00143	Small Cell Lung Carcinoma	GDSC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.6009
p.S4186Y	ACH-000803	Lung Cancer	CCLE	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.6009
p.S4186Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.6009
p.L482F	TCGA-55-8507	LUAD	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.2222
p.L482F	DO45412	LUAD	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.2222
p.T2585K	TCGA-56-8504	LUSC	TCGA	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.1111
p.T2585K	DO45437	LUSC	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.1111
p.P2564S	TCGA-59-2348	OV	TCGA	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.0556
p.P2564S	DO29508	OV	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.0556
p.L475V	TCGA-64-1676	LUAD	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.5654
p.L475V	TCGA-DR-A0ZM	CESC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.5654
p.L475V	DO6254	CESC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.5654
p.L475V	DO23629	LUAD	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.5654
p.L2586F	TCGA-66-2734	LUSC	TCGA	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.0833
p.L2586F	DO229035	LICA	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.0833
p.L2586F	DO26430	LUSC	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.0833
p.R375H	TCGA-77-8128	LUSC	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	TCGA-B5-A11S	UCEC	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	TCGA-FS-A1ZB	SKCM	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	TCGA-VN-A88N	PRAD	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	DO26464	LUSC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	DO229077	PRAD	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	DO49858	PRAD	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	DO37886	SKCM	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.R375H	DO41895	UCEC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1111
p.D2576E	TCGA-A7-A6VX	BRCA	TCGA	PPDY	ITCH	2574:2577	Mutation altering degron motif	0.5647
p.D2576E	DO50019	BRCA	ICGC	PPDY	ITCH	2574:2577	Mutation altering degron motif	0.5647
p.D350N	TCGA-AA-3977	COAD	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2222
p.D350N	DO8730	COAD	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2222
p.R2705Q	TCGA-AA-A00N	COAD	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.R2705Q	TCGA-AG-A002	READ	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.R2705Q	DO9876	COAD	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.R2705Q	SIDM00681	Colorectal Carcinoma	GDSC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.R2705Q	ACH-000252	Colon/Colorectal Cancer	CCLE	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.R2705Q	LS-1034	large intestine	COSMIC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.V2707A	TCGA-AF-4110	READ	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2222
p.V2707A	DO37380	READ	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2222
p.S374F	TCGA-AP-A1DK	UCEC	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0833
p.S374F	DO42033	UCEC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0833
p.D350Y	TCGA-AX-A05Z	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2222
p.D350Y	TCGA-E6-A1LX	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2222
p.D350Y	DO40884	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2222
p.D350Y	DO41020	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2222
p.L475I	TCGA-AX-A05Z	UCEC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.6063
p.L475I	DO222421	BTCA	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.6063
p.L475I	DO40884	UCEC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.6063
p.R472I	TCGA-B5-A0JY	UCEC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.8102
p.R472I	DO43041	UCEC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.8102
p.S2715N	TCGA-B5-A1MR	UCEC	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.5958
p.S2715N	DO41758	UCEC	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.5958
p.G340D	TCGA-B6-A2IU	BRCA	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.6087
p.G340D	DO4425	BRCA	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.6087
p.D331Y	TCGA-BF-A1Q0	SKCM	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1667
p.D331Y	TCGA-EP-A2KA	LIHC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1667
p.D331Y	DO23023	LIHC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1667
p.D331Y	DO47374	SKCM	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1667
p.D2722N	TCGA-BF-AAP1	SKCM	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2778
p.D2722N	TCGA-FW-A3R5	SKCM	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2778
p.D2722N	DO37406	SKCM	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2778
p.D2722N	DO219464	SKCM	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2778
p.C353W	TCGA-BH-A0HX	BRCA	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1389
p.C353W	DO5891	BRCA	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1389
p.E328D	TCGA-CA-6717	COAD	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.E328D	TCGA-QF-A5YS	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.E328D	DO8264	COAD	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.E328D	DO52426	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.K335N	TCGA-CG-5720	STAD	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2778
p.K335N	DO38623	STAD	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2778
p.D4246N	TCGA-CZ-5987	KIRC	TCGA	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.6932
p.D4246N	DO18701	KIRC	ICGC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.6932
p.P2574S	TCGA-D1-A17H	UCEC	TCGA	PPDY	ITCH	2574:2577	Mutation altering degron motif	0.6752
p.P2574S	DO41847	UCEC	ICGC	PPDY	ITCH	2574:2577	Mutation altering degron motif	0.6752
p.D337Y	TCGA-D1-A17Q	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7325
p.D337Y	DO41903	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7325
p.R336L	TCGA-D3-A2JP	SKCM	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.3056
p.R336L	DO47407	SKCM	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.3056
p.R336L	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.3056
p.R336L	ACH-000826	Lung Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.3056
p.R336L	CAL-12T	lung	COSMIC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.3056
p.G349R	TCGA-D3-A3C7	SKCM	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.25
p.G349R	DO47569	SKCM	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.25
p.L330I	TCGA-DD-A4NI	LIHC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1389
p.L330I	DO45025	LIHC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1389
p.T4247A	TCGA-DU-6392	LGG	TCGA	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.3056
p.T4247A	DO22237	LGG	ICGC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.3056
p.G2571W	TCGA-DZ-6132	KIRP	TCGA	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.25
p.G2571W	DO20919	KIRP	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.25
p.G2571V	TCGA-EE-A29X	SKCM	TCGA	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.25
p.G2571V	TCGA-ER-A19B	SKCM	TCGA	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.25
p.G2571V	DO37595	SKCM	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.25
p.G2571V	DO47491	SKCM	ICGC	PPDY	ITCH	2574:2577	Mutation rewiring degron network	0.25
p.Q463H	TCGA-EO-A22R	UCEC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.0833
p.Q463H	DO42713	UCEC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.0833
p.G377R	TCGA-EO-A3KX	UCEC	TCGA	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1667
p.G377R	DO219774	UCEC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1667
p.K335M	TCGA-F7-7848	HNSC	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2778
p.K335M	DO14198	HNSC	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.2778
p.K4178E	TCGA-FI-A2D5	UCEC	TCGA	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation substituting flanking lysine	0.25
p.K4178E	DO41331	UCEC	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation substituting flanking lysine	0.25
p.P2720L	TCGA-G4-6315	COAD	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.7582
p.P2720L	DO9522	COAD	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.7582
p.P2574Q	TCGA-G7-6797	KIRP	TCGA	PPDY	ITCH	2574:2577	Mutation altering degron motif	0.7035
p.P2574Q	DO20917	KIRP	ICGC	PPDY	ITCH	2574:2577	Mutation altering degron motif	0.7035
p.S351Y	TCGA-VQ-A8P2	STAD	TCGA	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1944
p.S351Y	DO51761	STAD	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.1944
p.R2705L	TCGA-YH-A8SY	PAAD	TCGA	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.R2705L	DO218974	PAAD	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1667
p.T373P	DO233107	GACA	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.T373P	DO230946	LUSC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.T4201N	DO233105	GACA	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation rewiring degron network	0.1111
p.R467C	DO233941	GACA	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation rewiring degron network	0.1944
p.E4254D	DO228212	LICA	ICGC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1111
p.K4182N	DO229015	LICA	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation substituting flanking lysine	0.3611
p.M391I	DO229015	LICA	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.V2707L	DO229029	LICA	ICGC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.2222
p.K347N	DO229036	LICA	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.3056
p.G389D	DO50970	LICA	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.3056
p.M391K	DO231866	LINC	ICGC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.P344S	DO229177	LMS	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.6752
p.P344L	DO229177	LMS	ICGC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7582
p.P344L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7582
p.P344L	ACH-000843	Lung Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7582
p.P344L	HARA	lung	COSMIC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7582
p.S4186F	DO222420	MELA	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.6871
p.R381K	SIDM00672	Hepatocellular Carcinoma	GDSC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.R381K	ACH-000625	Liver Cancer	CCLE	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.R381K	Hep_3B2_1-7	NS	COSMIC	VILHQE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.Q4240H	SIDM00524	Small Cell Lung Carcinoma	GDSC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.3056
p.Q4240H	ACH-000703	Lung Cancer	CCLE	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.3056
p.Q4240H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.3056
p.D4246G	SIDM00933	Breast Carcinoma	GDSC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.7198
p.D4246G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.7198
p.S2715G	SIDM00962	Chronic Myelogenous Leukemia	GDSC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.5882
p.S2715G	BV-173	haematopoietic and lymphoid tissue	COSMIC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.5882
p.E328K	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.E328K	ACH-000509	Lymphoma	CCLE	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.E328K	ACH-002240	Lymphoma	CCLE	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.E328K	H9	haematopoietic and lymphoid tissue	COSMIC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation rewiring degron network	0.0833
p.D337G	SIDM01045	Endometrial Carcinoma	GDSC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7198
p.D337G	ACH-000978	Endometrial/Uterine Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7198
p.D337G	EN	endometrium	COSMIC	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.7198
p.A4253S	SIDM01217	Other Blood Cancers	GDSC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1389
p.A4253S	ACH-002276	Leukemia	CCLE	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1389
p.A4253S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1389
p.N474H	SIDM00118	Colorectal Carcinoma	GDSC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.6312
p.N474H	ACH-001081	Colon/Colorectal Cancer	CCLE	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.6312
p.N474H	HCC2998	large intestine	COSMIC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.6312
p.R472T	SIDM00528	Breast Carcinoma	GDSC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.7876
p.R472T	ACH-000934	Breast Cancer	CCLE	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.7876
p.R472T	MDA-MB-361	breast	COSMIC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	472:478	Mutation altering degron motif	0.7876
p.S2706I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1944
p.M341T	ACH-001518	Endometrial/Uterine Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	337:346	Mutation altering degron motif	0.6312
p.Q4235H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1667
p.A4256S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.0556
p.S4181Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation rewiring degron network	0.2222
p.S4189Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.712
p.D4241G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.7198
p.A4242S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.7588
p.Q4243H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.7582
p.I4249V	COLO-824	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.25
p.D4245G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation altering degron motif	0.6087
p.S4175Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation rewiring degron network	0.0556
p.Q4239H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.2778
p.S2714G	BV-173	haematopoietic and lymphoid tissue	COSMIC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation altering degron motif	0.6993
p.I4255V	COLO-824	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.0833
p.S4185Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	4185:4193	Mutation altering degron motif	0.712
p.D4235G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1667
p.D4249G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.25
p.R2704Q	LS-1034	large intestine	COSMIC	NQGNSYSPAP	CBL_PTK	2711:2720	Mutation rewiring degron network	0.1389
p.A4252S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.1667
p.A4248S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	4241:4246	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RYR3

UniProt ID: Q15413

Entrez ID: 6263

Protein name: Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RYR3 in