DegronMD

Uniprot ID: Q15413

Source protein: Ryanodine receptor 3

Source gene: RYR3

Class: CBL_PTK

Location: 2711:2720

E3 ligase: CBL

DEGRON score: 0.9753

ASA_SCORE: 69.61

COIL: 0.8703

CONS_SCORE: 0.4081

DSS_SCORE: 0.4646

HELIX: 0.0673

FCONS_SCORE: 1.1006

RIG_SCORE: 0.6341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2705Q	TCGA-AA-A00N	COAD	TCGA	NQGNSYSPAP	CBL_PTK	0.1667
p.R2705Q	TCGA-AG-A002	READ	TCGA	NQGNSYSPAP	CBL_PTK	0.1667
p.R2705Q	DO9876	COAD	ICGC	NQGNSYSPAP	CBL_PTK	0.1667
p.R2705Q	SIDM00681	Colorectal Carcinoma	GDSC	NQGNSYSPAP	CBL_PTK	0.1667
p.R2705Q	ACH-000252	Colon/Colorectal Cancer	CCLE	NQGNSYSPAP	CBL_PTK	0.1667
p.R2705Q	LS-1034	large_intestine	COSMIC	NQGNSYSPAP	CBL_PTK	0.1667
p.V2707A	TCGA-AF-4110	READ	TCGA	NQGNSYSPAP	CBL_PTK	0.2222
p.V2707A	DO37380	READ	ICGC	NQGNSYSPAP	CBL_PTK	0.2222
p.S2715N	TCGA-B5-A1MR	UCEC	TCGA	NQGNSYSPAP	CBL_PTK	0.5958
p.S2715N	DO41758	UCEC	ICGC	NQGNSYSPAP	CBL_PTK	0.5958
p.D2722N	TCGA-BF-AAP1	SKCM	TCGA	NQGNSYSPAP	CBL_PTK	0.2778
p.D2722N	TCGA-FW-A3R5	SKCM	TCGA	NQGNSYSPAP	CBL_PTK	0.2778
p.D2722N	DO37406	SKCM	ICGC	NQGNSYSPAP	CBL_PTK	0.2778
p.D2722N	DO219464	SKCM	ICGC	NQGNSYSPAP	CBL_PTK	0.2778
p.P2720L	TCGA-G4-6315	COAD	TCGA	NQGNSYSPAP	CBL_PTK	0.7582
p.P2720L	DO9522	COAD	ICGC	NQGNSYSPAP	CBL_PTK	0.7582
p.R2705L	TCGA-YH-A8SY	PAAD	TCGA	NQGNSYSPAP	CBL_PTK	0.1667
p.R2705L	DO218974	PAAD	ICGC	NQGNSYSPAP	CBL_PTK	0.1667
p.V2707L	DO229029	LICA	ICGC	NQGNSYSPAP	CBL_PTK	0.2222
p.S2715G	SIDM00962	Chronic Myelogenous Leukemia	GDSC	NQGNSYSPAP	CBL_PTK	0.5882
p.S2715G	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	NQGNSYSPAP	CBL_PTK	0.5882
p.S2706I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	NQGNSYSPAP	CBL_PTK	0.1944
p.S2714G	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	NQGNSYSPAP	CBL_PTK	0.6993
p.R2704Q	LS-1034	large_intestine	COSMIC	NQGNSYSPAP	CBL_PTK	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15413	Ryanodine receptor 3	CBL_PTK	2711:2720	NQGNSYSPAP	CBL	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons