DegronMD

Uniprot ID: Q15413

Source protein: Ryanodine receptor 3

Source gene: RYR3

Class: LIG_APCC_ABBAyCdc20_2

Location: 472:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6092

ASA_SCORE: 81.8143

COIL: 0.29

CONS_SCORE: 0.7155

DSS_SCORE: 0.1968

HELIX: 0.7004

FCONS_SCORE: 1.1812

RIG_SCORE: 0.8084

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V485F	TCGA-06-6388	GBM	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V485F	DO14109	GBM	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N464K	TCGA-34-8455	LUSC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.N464K	DO50095	LUSC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R467H	TCGA-51-6867	LUSC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R467H	DO26477	LUSC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L482F	TCGA-55-8507	LUAD	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L482F	DO45412	LUAD	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L475V	TCGA-64-1676	LUAD	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L475V	TCGA-DR-A0ZM	CESC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L475V	DO6254	CESC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L475V	DO23629	LUAD	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L475I	TCGA-AX-A05Z	UCEC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.6063
p.L475I	DO222421	BTCA	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.6063
p.L475I	DO40884	UCEC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.6063
p.R472I	TCGA-B5-A0JY	UCEC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R472I	DO43041	UCEC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.8102
p.Q463H	TCGA-EO-A22R	UCEC	TCGA	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q463H	DO42713	UCEC	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R467C	DO233941	GACA	ICGC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.N474H	SIDM00118	Colorectal Carcinoma	GDSC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.6312
p.N474H	ACH-001081	Colon/Colorectal Cancer	CCLE	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.6312
p.N474H	HCC2998	large_intestine	COSMIC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.6312
p.R472T	SIDM00528	Breast Carcinoma	GDSC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.7876
p.R472T	ACH-000934	Breast Cancer	CCLE	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.7876
p.R472T	MDA-MB-361	breast	COSMIC	RQNLFKE	LIG_APCC_ABBAyCdc20_2	0.7876

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RQNLFKE

Degron related mutations and impact score

Drug responses associated with RYR3 mutations

All proteins holding degron of RQNLFKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15413	Ryanodine receptor 3	LIG_APCC_ABBAyCdc20_2	472:478	RQNLFKE	APC,CDC20,FZR1	0.6092	More...