DegronMD

Uniprot ID: Q15413

Source protein: Ryanodine receptor 3

Source gene: RYR3

Class: DEG_COP1_1

Location: 337:346

E3 ligase: COP1

DEGRON score: 0.8954

ASA_SCORE: 60.69

COIL: 0.7032

CONS_SCORE: 0.5602

DSS_SCORE: 0.3258

HELIX: 0.0847

FCONS_SCORE: 1.2186

RIG_SCORE: 0.7473

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D337E	TCGA-17-Z062	LUAD	TCGA	DIEGMGVPEI	DEG_COP1_1	0.5647
p.D350N	TCGA-AA-3977	COAD	TCGA	DIEGMGVPEI	DEG_COP1_1	0.2222
p.D350N	DO8730	COAD	ICGC	DIEGMGVPEI	DEG_COP1_1	0.2222
p.D350Y	TCGA-AX-A05Z	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.2222
p.D350Y	TCGA-E6-A1LX	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.2222
p.D350Y	DO40884	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.2222
p.D350Y	DO41020	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.2222
p.G340D	TCGA-B6-A2IU	BRCA	TCGA	DIEGMGVPEI	DEG_COP1_1	0.6087
p.G340D	DO4425	BRCA	ICGC	DIEGMGVPEI	DEG_COP1_1	0.6087
p.D331Y	TCGA-BF-A1Q0	SKCM	TCGA	DIEGMGVPEI	DEG_COP1_1	0.1667
p.D331Y	TCGA-EP-A2KA	LIHC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.1667
p.D331Y	DO23023	LIHC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.1667
p.D331Y	DO47374	SKCM	ICGC	DIEGMGVPEI	DEG_COP1_1	0.1667
p.C353W	TCGA-BH-A0HX	BRCA	TCGA	DIEGMGVPEI	DEG_COP1_1	0.1389
p.C353W	DO5891	BRCA	ICGC	DIEGMGVPEI	DEG_COP1_1	0.1389
p.E328D	TCGA-CA-6717	COAD	TCGA	DIEGMGVPEI	DEG_COP1_1	0.0833
p.E328D	TCGA-QF-A5YS	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.0833
p.E328D	DO8264	COAD	ICGC	DIEGMGVPEI	DEG_COP1_1	0.0833
p.E328D	DO52426	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.0833
p.K335N	TCGA-CG-5720	STAD	TCGA	DIEGMGVPEI	DEG_COP1_1	0.2778
p.K335N	DO38623	STAD	ICGC	DIEGMGVPEI	DEG_COP1_1	0.2778
p.D337Y	TCGA-D1-A17Q	UCEC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.7325
p.D337Y	DO41903	UCEC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.7325
p.R336L	TCGA-D3-A2JP	SKCM	TCGA	DIEGMGVPEI	DEG_COP1_1	0.3056
p.R336L	DO47407	SKCM	ICGC	DIEGMGVPEI	DEG_COP1_1	0.3056
p.R336L	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	DIEGMGVPEI	DEG_COP1_1	0.3056
p.R336L	ACH-000826	Lung Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	0.3056
p.R336L	CAL-12T	lung	COSMIC	DIEGMGVPEI	DEG_COP1_1	0.3056
p.G349R	TCGA-D3-A3C7	SKCM	TCGA	DIEGMGVPEI	DEG_COP1_1	0.25
p.G349R	DO47569	SKCM	ICGC	DIEGMGVPEI	DEG_COP1_1	0.25
p.L330I	TCGA-DD-A4NI	LIHC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.1389
p.L330I	DO45025	LIHC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.1389
p.K335M	TCGA-F7-7848	HNSC	TCGA	DIEGMGVPEI	DEG_COP1_1	0.2778
p.K335M	DO14198	HNSC	ICGC	DIEGMGVPEI	DEG_COP1_1	0.2778
p.S351Y	TCGA-VQ-A8P2	STAD	TCGA	DIEGMGVPEI	DEG_COP1_1	0.1944
p.S351Y	DO51761	STAD	ICGC	DIEGMGVPEI	DEG_COP1_1	0.1944
p.K347N	DO229036	LICA	ICGC	DIEGMGVPEI	DEG_COP1_1	0.3056
p.P344S	DO229177	LMS	ICGC	DIEGMGVPEI	DEG_COP1_1	0.6752
p.P344L	DO229177	LMS	ICGC	DIEGMGVPEI	DEG_COP1_1	0.7582
p.P344L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DIEGMGVPEI	DEG_COP1_1	0.7582
p.P344L	ACH-000843	Lung Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	0.7582
p.P344L	HARA	lung	COSMIC	DIEGMGVPEI	DEG_COP1_1	0.7582
p.E328K	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	DIEGMGVPEI	DEG_COP1_1	0.0833
p.E328K	ACH-000509	Lymphoma	CCLE	DIEGMGVPEI	DEG_COP1_1	0.0833
p.E328K	ACH-002240	Lymphoma	CCLE	DIEGMGVPEI	DEG_COP1_1	0.0833
p.E328K	H9	haematopoietic_and_lymphoid_tissue	COSMIC	DIEGMGVPEI	DEG_COP1_1	0.0833
p.D337G	SIDM01045	Endometrial Carcinoma	GDSC	DIEGMGVPEI	DEG_COP1_1	0.7198
p.D337G	ACH-000978	Endometrial/Uterine Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	0.7198
p.D337G	EN	endometrium	COSMIC	DIEGMGVPEI	DEG_COP1_1	0.7198
p.M341T	ACH-001518	Endometrial/Uterine Cancer	CCLE	DIEGMGVPEI	DEG_COP1_1	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DIEGMGVPEI

Degron related mutations and impact score

Drug responses associated with RYR3 mutations

All proteins holding degron of DIEGMGVPEI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15413	Ryanodine receptor 3	DEG_COP1_1	337:346	DIEGMGVPEI	COP1	0.8954	More...