DegronMD

Uniprot ID: Q15413

Source protein: Ryanodine receptor 3

Source gene: RYR3

Class: LIG_APCC_ABBA_1

Location: 383:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5634

ASA_SCORE: 87.8167

COIL: 0.5595

CONS_SCORE: 0.5698

DSS_SCORE: 0.3753

HELIX: 0.0515

FCONS_SCORE: 1.0351

RIG_SCORE: 0.7688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K382T	TCGA-21-5787	LUSC	TCGA	VILHQE	LIG_APCC_ABBA_1	0.3056
p.K382T	DO26605	LUSC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.3056
p.R375H	TCGA-77-8128	LUSC	TCGA	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	TCGA-B5-A11S	UCEC	TCGA	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	TCGA-FS-A1ZB	SKCM	TCGA	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	TCGA-VN-A88N	PRAD	TCGA	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	DO26464	LUSC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	DO229077	PRAD	ICGC	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	DO49858	PRAD	ICGC	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	DO37886	SKCM	ICGC	VILHQE	LIG_APCC_ABBA_1	0.1111
p.R375H	DO41895	UCEC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.1111
p.S374F	TCGA-AP-A1DK	UCEC	TCGA	VILHQE	LIG_APCC_ABBA_1	0.0833
p.S374F	DO42033	UCEC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.0833
p.G377R	TCGA-EO-A3KX	UCEC	TCGA	VILHQE	LIG_APCC_ABBA_1	0.1667
p.G377R	DO219774	UCEC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.1667
p.T373P	DO233107	GACA	ICGC	VILHQE	LIG_APCC_ABBA_1	0.0556
p.T373P	DO230946	LUSC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.0556
p.M391I	DO229015	LICA	ICGC	VILHQE	LIG_APCC_ABBA_1	0.25
p.G389D	DO50970	LICA	ICGC	VILHQE	LIG_APCC_ABBA_1	0.3056
p.M391K	DO231866	LINC	ICGC	VILHQE	LIG_APCC_ABBA_1	0.25
p.R381K	SIDM00672	Hepatocellular Carcinoma	GDSC	VILHQE	LIG_APCC_ABBA_1	0.2778
p.R381K	ACH-000625	Liver Cancer	CCLE	VILHQE	LIG_APCC_ABBA_1	0.2778
p.R381K	Hep_3B2_1-7	NS	COSMIC	VILHQE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15413	Ryanodine receptor 3	LIG_APCC_ABBA_1	383:388	VILHQE	APC,CDC20,FZR1	0.5634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons