DegronMD

Uniprot ID: Q15413

Source protein: Ryanodine receptor 3

Source gene: RYR3

Class: DEG_MDM2_SWIB_1

Location: 4185:4193

E3 ligase: MDM2

DEGRON score: 0.6548

ASA_SCORE: 93.8222

COIL: 0.0961

CONS_SCORE: 0.3434

DSS_SCORE: 0.0001

HELIX: 0.8964

FCONS_SCORE: 1.2065

RIG_SCORE: 1.1359

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4177V	TCGA-06-5416	GBM	TCGA	FSFFWMLFV	DEG_MDM2_SWIB_1	0.1111
p.A4177V	DO10880	GBM	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.1111
p.S4186Y	TCGA-55-7724	LUAD	TCGA	FSFFWMLFV	DEG_MDM2_SWIB_1	0.6009
p.S4186Y	DO45373	LUAD	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.6009
p.S4186Y	SIDM00143	Small Cell Lung Carcinoma	GDSC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.6009
p.S4186Y	ACH-000803	Lung Cancer	CCLE	FSFFWMLFV	DEG_MDM2_SWIB_1	0.6009
p.S4186Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.6009
p.K4178E	TCGA-FI-A2D5	UCEC	TCGA	FSFFWMLFV	DEG_MDM2_SWIB_1	0.25
p.K4178E	DO41331	UCEC	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.25
p.T4201N	DO233105	GACA	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.1111
p.K4182N	DO229015	LICA	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.3611
p.S4186F	DO222420	MELA	ICGC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.6871
p.S4181Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.2222
p.S4189Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.712
p.S4175Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.0556
p.S4185Y	COLO-668	lung	COSMIC	FSFFWMLFV	DEG_MDM2_SWIB_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15413	Ryanodine receptor 3	DEG_MDM2_SWIB_1	4185:4193	FSFFWMLFV	MDM2	0.6548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons