DegronMD

Uniprot ID: Q15413

Source protein: Ryanodine receptor 3

Source gene: RYR3

Class: LIG_APCC_ABBA_1

Location: 4241:4246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.76

ASA_SCORE: 75.8833

COIL: 0.7588

CONS_SCORE: 0.2799

DSS_SCORE: 0.5833

HELIX: 0.1743

FCONS_SCORE: 1.0391

RIG_SCORE: 0.7727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D4246N	TCGA-CZ-5987	KIRC	TCGA	FGIHDD	LIG_APCC_ABBA_1	0.6932
p.D4246N	DO18701	KIRC	ICGC	FGIHDD	LIG_APCC_ABBA_1	0.6932
p.T4247A	TCGA-DU-6392	LGG	TCGA	FGIHDD	LIG_APCC_ABBA_1	0.3056
p.T4247A	DO22237	LGG	ICGC	FGIHDD	LIG_APCC_ABBA_1	0.3056
p.E4254D	DO228212	LICA	ICGC	FGIHDD	LIG_APCC_ABBA_1	0.1111
p.Q4240H	SIDM00524	Small Cell Lung Carcinoma	GDSC	FGIHDD	LIG_APCC_ABBA_1	0.3056
p.Q4240H	ACH-000703	Lung Cancer	CCLE	FGIHDD	LIG_APCC_ABBA_1	0.3056
p.Q4240H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.3056
p.D4246G	SIDM00933	Breast Carcinoma	GDSC	FGIHDD	LIG_APCC_ABBA_1	0.7198
p.D4246G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.7198
p.A4253S	SIDM01217	Other Blood Cancers	GDSC	FGIHDD	LIG_APCC_ABBA_1	0.1389
p.A4253S	ACH-002276	Leukemia	CCLE	FGIHDD	LIG_APCC_ABBA_1	0.1389
p.A4253S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.1389
p.Q4235H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.1667
p.A4256S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.0556
p.D4241G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.7198
p.A4242S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.7588
p.Q4243H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.7582
p.I4249V	COLO-824	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.25
p.D4245G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.6087
p.Q4239H	DMS-79	lung	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.2778
p.I4255V	COLO-824	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.0833
p.D4235G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.1667
p.D4249G	CAL-51	breast	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.25
p.A4252S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.1667
p.A4248S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	FGIHDD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15413	Ryanodine receptor 3	LIG_APCC_ABBA_1	4241:4246	FGIHDD	APC,CDC20,FZR1	0.76	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FGIHDD

Degron related mutations and impact score

Drug responses associated with RYR3 mutations

All proteins holding degron of FGIHDD