DegronMD - Q4L180(FILIP1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R820C	TCGA-06-5858	GBM	TCGA	PPDY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.V822A	TCGA-25-2393	OV	TCGA	PPDY	ITCH	809:812	Mutation rewiring degron network	0.0556
p.E964K	TCGA-A5-A0G2	UCEC	TCGA	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1944
p.E964K	TCGA-AX-A2HC	UCEC	TCGA	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1944
p.E964K	TCGA-EO-A22X	UCEC	TCGA	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1944
p.R820H	TCGA-A5-A0G2	UCEC	TCGA	PPDY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.T1112A	TCGA-B5-A1MW	UCEC	TCGA	ITITPTAT	DEG_SCF_FBW7_1	1111:1118	Mutation altering degron motif	0.6028
p.P1119S	TCGA-BA-4078	HNSC	TCGA	ITITPTAT	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.3056
p.L818M	TCGA-DX-AB2V	SARC	TCGA	PPDY	ITCH	809:812	Mutation rewiring degron network	0.1667
p.T994I	TCGA-GM-A2DD	BRCA	TCGA	LTPERT	DEG_SCF_FBW7_1	993:998	Mutation altering degron motif	0.8189
p.R1122G	TCGA-XF-A9T5	BLCA	TCGA	ITITPTAT	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.2222
p.A952V	SIDM01296	Esophageal Carcinoma	GDSC	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.2778
p.S1000P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LTPERT	DEG_SCF_FBW7_1	993:998	Mutation blocking phosphorylation signal	0.7222
p.S1000P	ACH-001669	Leukemia	CCLE	LTPERT	DEG_SCF_FBW7_1	993:998	Mutation blocking phosphorylation signal	0.7222
p.S1000P	ACH-002238	Leukemia	CCLE	LTPERT	DEG_SCF_FBW7_1	993:998	Mutation blocking phosphorylation signal	0.7222
p.S1000P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LTPERT	DEG_SCF_FBW7_1	993:998	Mutation blocking phosphorylation signal	0.7222
p.A952T	SIDM00245	Small Cell Lung Carcinoma	GDSC	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.2778
p.A952T	ACH-001131	Skin Cancer	CCLE	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.2778
p.A952T	ACH-001958	lung	CCLE	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.2778
p.A952T	MS-1	lung	COSMIC	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.2778
p.I946M	SIDM01608	Endometrial Carcinoma	GDSC	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1111
p.I946M	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITPVKS	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1111
p.L815R	ACH-000237	Ovarian Cancer	CCLE	PPDY	ITCH	809:812	Mutation rewiring degron network	0.25
p.T1103K	ACH-001645	Skin Cancer	CCLE	ITITPTAT	DEG_SCF_FBW7_1	1111:1118	Mutation rewiring degron network	0.1111
p.W802R	LNCaP-Clone-FGC	prostate	COSMIC	PPDY	ITCH	809:812	Mutation rewiring degron network	0.1389

Kaplan plot for FILIP1L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FILIP1L

UniProt ID: Q4L180

Entrez ID: 11259

Protein name: Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FILIP1L in