DegronMD

Uniprot ID: Q4L180

Source protein: Filamin A-interacting protein 1-like

Source gene: FILIP1L

Class: DEG_SCF_FBW7_1

Location: 993:998

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 83.3667

COIL: 0.7957

CONS_SCORE: 0.7063

DSS_SCORE: 0.6211

HELIX: 0.113

FCONS_SCORE: 1.0689

RIG_SCORE: 0.6966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T994I	TCGA-GM-A2DD	BRCA	TCGA	LTPERT	DEG_SCF_FBW7_1	0.8189
p.S1000P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LTPERT	DEG_SCF_FBW7_1	0.7222
p.S1000P	ACH-001669	Leukemia	CCLE	LTPERT	DEG_SCF_FBW7_1	0.7222
p.S1000P	ACH-002238	Leukemia	CCLE	LTPERT	DEG_SCF_FBW7_1	0.7222
p.S1000P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LTPERT	DEG_SCF_FBW7_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4L180	Filamin A-interacting protein 1-like	DEG_SCF_FBW7_1	993:998	LTPERT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons