DegronMD

Uniprot ID: Q4L180

Source protein: Filamin A-interacting protein 1-like

Source gene: FILIP1L

Class: DEG_SCF_FBW7_1

Location: 954:959

E3 ligase: FBXW7

DEGRON score: 0.7059

ASA_SCORE: 90.55

COIL: 0.8988

CONS_SCORE: 0.618

DSS_SCORE: 0.4554

HELIX: 0.0262

FCONS_SCORE: 1.0301

RIG_SCORE: 0.7546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E964K	TCGA-A5-A0G2	UCEC	TCGA	ITPVKS	DEG_SCF_FBW7_1	0.1944
p.E964K	TCGA-AX-A2HC	UCEC	TCGA	ITPVKS	DEG_SCF_FBW7_1	0.1944
p.E964K	TCGA-EO-A22X	UCEC	TCGA	ITPVKS	DEG_SCF_FBW7_1	0.1944
p.A952V	SIDM01296	Esophageal Carcinoma	GDSC	ITPVKS	DEG_SCF_FBW7_1	0.2778
p.A952T	SIDM00245	Small Cell Lung Carcinoma	GDSC	ITPVKS	DEG_SCF_FBW7_1	0.2778
p.A952T	ACH-001131	Skin Cancer	CCLE	ITPVKS	DEG_SCF_FBW7_1	0.2778
p.A952T	ACH-001958	lung	CCLE	ITPVKS	DEG_SCF_FBW7_1	0.2778
p.A952T	MS-1	lung	COSMIC	ITPVKS	DEG_SCF_FBW7_1	0.2778
p.I946M	SIDM01608	Endometrial Carcinoma	GDSC	ITPVKS	DEG_SCF_FBW7_1	0.1111
p.I946M	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITPVKS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4L180	Filamin A-interacting protein 1-like	DEG_SCF_FBW7_1	954:959	ITPVKS	FBXW7	0.7059	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons