DegronMD

Uniprot ID: Q4L180

Source protein: Filamin A-interacting protein 1-like

Source gene: FILIP1L

Class: DEG_SCF_FBW7_1

Location: 1111:1118

E3 ligase: FBXW7

DEGRON score: 0.7002

ASA_SCORE: 56.3125

COIL: 0.5994

CONS_SCORE: 0.7313

DSS_SCORE: 0.4989

HELIX: 0.0098

FCONS_SCORE: 1.0362

RIG_SCORE: 0.758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1112A	TCGA-B5-A1MW	UCEC	TCGA	ITITPTAT	DEG_SCF_FBW7_1	0.6028
p.P1119S	TCGA-BA-4078	HNSC	TCGA	ITITPTAT	DEG_SCF_FBW7_1	0.3056
p.R1122G	TCGA-XF-A9T5	BLCA	TCGA	ITITPTAT	DEG_SCF_FBW7_1	0.2222
p.T1103K	ACH-001645	Skin Cancer	CCLE	ITITPTAT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4L180	Filamin A-interacting protein 1-like	DEG_SCF_FBW7_1	1111:1118	ITITPTAT	FBXW7	0.7002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons