DegronMD - Q9P2J2(IGSF9)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S976P	TCGA-A5-A0VP	UCEC	TCGA	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation altering degron motif	0.7863
p.V740L	TCGA-AJ-A23O	UCEC	TCGA	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.0833
p.V740L	DO43290	UCEC	ICGC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.0833
p.R968H	TCGA-AP-A051	UCEC	TCGA	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.2778
p.R968H	DO42673	UCEC	ICGC	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.2778
p.R968H	ACH-002272	Lymphoma	CCLE	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.2778
p.P227T	TCGA-AP-A1DK	UCEC	TCGA	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation altering degron motif	0.7031
p.P227T	DO42033	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation altering degron motif	0.7031
p.G225E	TCGA-AX-A0J1	UCEC	TCGA	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation rewiring degron network	0.3056
p.G225E	DO41199	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation rewiring degron network	0.3056
p.S723L	TCGA-EE-A2MR	SKCM	TCGA	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6556
p.R724H	TCGA-EY-A215	UCEC	TCGA	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.8244
p.R724H	DO42665	UCEC	ICGC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.8244
p.P978S	DO225150	BRCA	ICGC	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.2778
p.V228I	DO229383	BTCA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation altering degron motif	0.7076
p.R944H	DO234459	ESAD	ICGC	PPDY	ITCH	952:955	Mutation rewiring degron network	0.1111
p.N239I	DO233167	GACA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation rewiring degron network	0.0833
p.L944I	DO229019	LICA	ICGC	PPDY	ITCH	952:955	Mutation rewiring degron network	0.1111
p.P226T	DO229029	LICA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation altering degron motif	0.7031
p.D957Y	DO230538	LUSC	ICGC	PPDY	ITCH	952:955	Mutation rewiring degron network	0.2778
p.P226L	DO220903	MELA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation altering degron motif	0.7582
p.G731R	DO229446	SKCA	ICGC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7568
p.V231G	DO218863	SKCA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation rewiring degron network	0.3056
p.K234Q	DO38571	STAD	ICGC	PPVIV	DEG_Kelch_actinfilin_1	226:230	Mutation substituting flanking lysine	0.3333
p.S960P	DO42600	UCEC	ICGC	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.0556
p.S960P	DO42600	UCEC	ICGC	PPDY	ITCH	952:955	Mutation rewiring degron network	0.1944
p.P728L	SIDM00095	Glioblastoma	GDSC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6471
p.P728L	ACH-000504	Brain Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6471
p.P728L	SNB75	central nervous system	COSMIC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6471
p.Y721C	SIDM01045	Endometrial Carcinoma	GDSC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.2778
p.Y721C	ACH-000978	Endometrial/Uterine Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.2778
p.Y721C	EN	endometrium	COSMIC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.2778
p.T725M	SIDM01443	Gastric Carcinoma	GDSC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6312
p.T725M	ACH-000344	Gastric Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6312
p.A984V	ACH-000622	Brain Cancer	CCLE	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.1111
p.A984V	KNS-42	central nervous system	COSMIC	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.1111
p.T725P	ACH-000832	Head and Neck Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.5919
p.T725P	CAL-27	upper aerodigestive tract	COSMIC	SRTQLPGLL	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.5919
p.A968V	KNS-42	central nervous system	COSMIC	PETPPVS	DEG_SCF_FBW7_1	970:976	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF9

UniProt ID: Q9P2J2

Entrez ID: 57549

Protein name: Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF9 in