DegronMD

Uniprot ID: Q9P2J2

Source protein: Protein turtle homolog A

Source gene: IGSF9

Class: DEG_Kelch_actinfilin_1

Location: 226:230

E3 ligase: CUL3,KLHL17

DEGRON score: 0.6089

ASA_SCORE: 49.36

COIL: 0.4522

CONS_SCORE: 0.6316

DSS_SCORE: 0.307

HELIX: 0.0066

FCONS_SCORE: 1.0712

RIG_SCORE: 0.813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P227T	TCGA-AP-A1DK	UCEC	TCGA	PPVIV	DEG_Kelch_actinfilin_1	0.7031
p.P227T	DO42033	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.7031
p.G225E	TCGA-AX-A0J1	UCEC	TCGA	PPVIV	DEG_Kelch_actinfilin_1	0.3056
p.G225E	DO41199	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.3056
p.V228I	DO229383	BTCA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.7076
p.N239I	DO233167	GACA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.0833
p.P226T	DO229029	LICA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.7031
p.P226L	DO220903	MELA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.7582
p.V231G	DO218863	SKCA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.3056
p.K234Q	DO38571	STAD	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons