DLG4
UniProt ID: P78352
Entrez ID: 1742
Protein name: Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Requ...
FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}.
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GO - Biological processes (BP):
AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; dendritic spine morphogenesis [GO:0060997]; establishment of protein localization [GO:0045184]; establishment or maintenance...
AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; dendritic spine morphogenesis [GO:0060997]; establishment of protein localization [GO:0045184]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; learning [GO:0007612]; locomotory exploration behavior [GO:0035641]; negative regulation of receptor internalization [GO:0002091]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of synaptic transmission [GO:0050806]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein-containing complex assembly [GO:0065003]; protein localization to synapse [GO:0035418]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of grooming behavior [GO:2000821]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synaptic vesicle maturation [GO:0016188]; vocalization behavior [GO:0071625]
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GO - Molecular function (MF):
acetylcholine receptor binding [GO:0033130]; beta-1 adrenergic receptor binding [GO:0031697]; beta-2 adrenergic receptor binding [GO:0031698]; D1 dopamine receptor binding [GO:0031748]; frizzled binding [GO:0005109]; immunoglobulin binding [GO:0019865]; ionotropic glutamate receptor binding [GO:0035...
acetylcholine receptor binding [GO:0033130]; beta-1 adrenergic receptor binding [GO:0031697]; beta-2 adrenergic receptor binding [GO:0031698]; D1 dopamine receptor binding [GO:0031748]; frizzled binding [GO:0005109]; immunoglobulin binding [GO:0019865]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; kinesin binding [GO:0019894]; neuroligin family protein binding [GO:0097109]; P2Y1 nucleotide receptor binding [GO:0031812]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein C-terminus binding [GO:0008022]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; scaffold protein binding [GO:0097110]; structural constituent of postsynaptic density [GO:0098919]
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GO - Cellular component (CC):
adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; anchored component of postsynaptic density membrane [GO:0099031]; cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite ...
adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; anchored component of postsynaptic density membrane [GO:0099031]; cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; voltage-gated potassium channel complex [GO:0008076]
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DLG4
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*NOTE: the Kaplan plots were collected from OncoLnc