DegronMD

Uniprot ID: P78352

Source protein: Disks large homolog 4

Source gene: DLG4

Class: DEG_Kelch_actinfilin_1

Location: 36:40

E3 ligase: CUL3,KLHL17

DEGRON score: 0.9964

ASA_SCORE: 76.84

COIL: 0.8546

CONS_SCORE: 0.4172

DSS_SCORE: 0.6298

HELIX: 0.0188

FCONS_SCORE: 1.0476

RIG_SCORE: 0.6851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D43E	TCGA-DM-A28A	COAD	TCGA	PPVIV	DEG_Kelch_actinfilin_1	0.25
p.D43E	DO7878	COAD	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.25
p.D43Y	TCGA-S5-A6DX	BLCA	TCGA	PPVIV	DEG_Kelch_actinfilin_1	0.25
p.D43Y	DO51903	BLCA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.25
p.D43Y	DO41488	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.25
p.A27D	DO229008	LICA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.0833
p.P26L	DO23342	LINC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.0556
p.L27F	DO222595	MELA	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.0833
p.G49E	DO41020	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.0833
p.E46D	DO41644	UCEC	ICGC	PPVIV	DEG_Kelch_actinfilin_1	0.1667
p.D43N	SIDM01649	Non-Cancerous	GDSC	PPVIV	DEG_Kelch_actinfilin_1	0.25
p.D43N	SIDM00184	Melanoma	GDSC	PPVIV	DEG_Kelch_actinfilin_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons