DegronMD

Uniprot ID: Q9P2J2

Source protein: Protein turtle homolog A

Source gene: IGSF9

Class: DEG_APCC_DBOX_1

Location: 723:731

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6316

ASA_SCORE: 77.7333

COIL: 0.8597

CONS_SCORE: 0.4235

DSS_SCORE: 0.1593

HELIX: 0.0494

FCONS_SCORE: 0.8912

RIG_SCORE: 0.7821

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R724H	TCGA-EY-A215	UCEC	TCGA	SRTQLPGLL	DEG_APCC_DBOX_1	0.8244
p.R724H	DO42665	UCEC	ICGC	SRTQLPGLL	DEG_APCC_DBOX_1	0.8244
p.G731R	DO229446	SKCA	ICGC	SRTQLPGLL	DEG_APCC_DBOX_1	0.7568
p.S723L	TCGA-EE-A2MR	SKCM	TCGA	SRTQLPGLL	DEG_APCC_DBOX_1	0.6556
p.P728L	SIDM00095	Glioblastoma	GDSC	SRTQLPGLL	DEG_APCC_DBOX_1	0.6471
p.P728L	ACH-000504	Brain Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	0.6471
p.P728L	SNB75	central_nervous_system	COSMIC	SRTQLPGLL	DEG_APCC_DBOX_1	0.6471
p.T725M	SIDM01443	Gastric Carcinoma	GDSC	SRTQLPGLL	DEG_APCC_DBOX_1	0.6312
p.T725M	ACH-000344	Gastric Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	0.6312
p.T725P	ACH-000832	Head and Neck Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	0.5919
p.T725P	CAL-27	upper_aerodigestive_tract	COSMIC	SRTQLPGLL	DEG_APCC_DBOX_1	0.5919
p.Y721C	SIDM01045	Endometrial Carcinoma	GDSC	SRTQLPGLL	DEG_APCC_DBOX_1	0.2778
p.Y721C	ACH-000978	Endometrial/Uterine Cancer	CCLE	SRTQLPGLL	DEG_APCC_DBOX_1	0.2778
p.Y721C	EN	endometrium	COSMIC	SRTQLPGLL	DEG_APCC_DBOX_1	0.2778
p.V740L	TCGA-AJ-A23O	UCEC	TCGA	SRTQLPGLL	DEG_APCC_DBOX_1	0.0833
p.V740L	DO43290	UCEC	ICGC	SRTQLPGLL	DEG_APCC_DBOX_1	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2J2	Protein turtle homolog A	DEG_APCC_DBOX_1	723:731	SRTQLPGLL	APC,CDC20,FZR1	0.6316	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons