DegronMD

Uniprot ID: Q9P2J2

Source protein: Protein turtle homolog A

Source gene: IGSF9

Class: DEG_SCF_FBW7_1

Location: 970:976

E3 ligase: FBXW7

DEGRON score: 0.978

ASA_SCORE: 94.2429

COIL: 0.978

CONS_SCORE: 0.366

DSS_SCORE: 0.632

HELIX: 0.0104

FCONS_SCORE: 0.9154

RIG_SCORE: 0.5968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S976P	TCGA-A5-A0VP	UCEC	TCGA	PETPPVS	DEG_SCF_FBW7_1	0.7863
p.R968H	TCGA-AP-A051	UCEC	TCGA	PETPPVS	DEG_SCF_FBW7_1	0.2778
p.R968H	DO42673	UCEC	ICGC	PETPPVS	DEG_SCF_FBW7_1	0.2778
p.R968H	ACH-002272	Lymphoma	CCLE	PETPPVS	DEG_SCF_FBW7_1	0.2778
p.P978S	DO225150	BRCA	ICGC	PETPPVS	DEG_SCF_FBW7_1	0.2778
p.S960P	DO42600	UCEC	ICGC	PETPPVS	DEG_SCF_FBW7_1	0.0556
p.A984V	ACH-000622	Brain Cancer	CCLE	PETPPVS	DEG_SCF_FBW7_1	0.1111
p.A984V	KNS-42	central_nervous_system	COSMIC	PETPPVS	DEG_SCF_FBW7_1	0.1111
p.A968V	KNS-42	central_nervous_system	COSMIC	PETPPVS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2J2	Protein turtle homolog A	DEG_SCF_FBW7_1	970:976	PETPPVS	FBXW7	0.978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons