DegronMD

Uniprot ID: O43390

Source protein: Heterogeneous nuclear ribonucleoprotein R

Source gene: HNRNPR

Class: ITCH

Location: 461:464

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6735

ASA_SCORE: 45.15

COIL: 0.8605

CONS_SCORE: 0.3493

DSS_SCORE: 0.3327

HELIX: 0.0455

FCONS_SCORE: 0.9717

RIG_SCORE: 0.7652

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S463A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.7588
p.S463A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.7588
p.S463A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.7588
p.Y461N	TCGA-AD-6895	COAD	TCGA	PPDY	ITCH	0.7059
p.Y461N	DO8938	COAD	ICGC	PPDY	ITCH	0.7059
p.Q463E	S-117	soft_tissue	COSMIC	PPDY	ITCH	0.6744
p.Q463E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.6744
p.S460F	MDA-MB-361	breast	COSMIC	PPDY	ITCH	0.3056
p.Y467C	TCGA-CG-5721	STAD	TCGA	PPDY	ITCH	0.25
p.Y467C	DO38192	STAD	ICGC	PPDY	ITCH	0.25
p.R467H	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.25
p.G469D	TCGA-DM-A1DA	COAD	TCGA	PPDY	ITCH	0.1944
p.G469D	DO7852	COAD	ICGC	PPDY	ITCH	0.1944
p.G456W	TCGA-E2-A15J	BRCA	TCGA	PPDY	ITCH	0.1944
p.G456W	TCGA-YF-AA3L	BLCA	TCGA	PPDY	ITCH	0.1944
p.G456W	DO51951	BLCA	ICGC	PPDY	ITCH	0.1944
p.G456W	DO4116	BRCA	ICGC	PPDY	ITCH	0.1944
p.R454H	TCGA-BR-8361	STAD	TCGA	PPDY	ITCH	0.1389
p.R454H	DO48032	STAD	ICGC	PPDY	ITCH	0.1389
p.G454S	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.1389
p.D472N	TCGA-AD-6895	COAD	TCGA	PPDY	ITCH	0.1111
p.D472N	DO8938	COAD	ICGC	PPDY	ITCH	0.1111
p.D472E	TCGA-AP-A051	UCEC	TCGA	PPDY	ITCH	0.1111
p.D472E	DO42673	UCEC	ICGC	PPDY	ITCH	0.1111
p.R452W	TCGA-BS-A0UV	UCEC	TCGA	PPDY	ITCH	0.0833

Showing 1 to 25 of 30 entries

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Drug responses associated with HNRNPR mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPDY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13405	39S ribosomal protein L49, mitochondrial	ITCH	32:35	PPDY	ITCH,NEDD4	0.9394	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	ITCH	282:285	PPDY	ITCH,NEDD4	0.8863	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	ITCH	468:471	PPDY	ITCH,NEDD4	0.9965	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	ITCH	436:439	PPDY	ITCH,NEDD4	0.9989	More...
P20810	Calpastatin	ITCH	478:481	PPDY	ITCH,NEDD4	0.9995	More...
O95985	DNA topoisomerase 3-beta-1	ITCH	490:493	PPDY	ITCH,NEDD4	0.8044	More...
Q6ZR08	Dynein axonemal heavy chain 12	ITCH	78:81	PPDY	ITCH,NEDD4	0.9568	More...
Q8TE73	Dynein axonemal heavy chain 5	ITCH	4368:4371	PPDY	ITCH,NEDD4	0.9769	More...
Q96JB1	Dynein axonemal heavy chain 8	ITCH	4233:4236	PPDY	ITCH,NEDD4	0.9067	More...
Q8N7E2	E3 ubiquitin-protein ligase CBLL2	ITCH	256:259	PPDY	ITCH,NEDD4	0.9915	More...
Q9UBS8	E3 ubiquitin-protein ligase RNF14	ITCH	80:83	PPDY	ITCH,NEDD4	0.791	More...
Q96I24	Far upstream element-binding protein 3	ITCH	540:543	PPDY	ITCH,NEDD4	0.995	More...
Q4L180	Filamin A-interacting protein 1-like	ITCH	809:812	PPDY	ITCH,NEDD4	0.861	More...
Q5T442	Gap junction gamma-2 protein	ITCH	330:333	PPDY	ITCH,NEDD4	0.9661	More...
Q8IUY3	GRAM domain-containing protein 2A	ITCH	41:44	PPDY	ITCH,NEDD4	0.9404	More...
P61296	Heart- and neural crest derivatives-expressed protein 2	ITCH	55:58	PPDY	ITCH,NEDD4	0.829	More...
O43390	Heterogeneous nuclear ribonucleoprotein R	ITCH	461:464	PPDY	ITCH,NEDD4	0.6735	More...
Q6UWN5	Ly6/PLAUR domain-containing protein 5	ITCH	94:97	PPDY	ITCH,NEDD4	0.7174	More...
Q8IZL2	Mastermind-like protein 2	ITCH	127:130	PPDY	ITCH,NEDD4	0.9403	More...
Q8IZL2	Mastermind-like protein 2	ITCH	798:801	PPDY	ITCH,NEDD4	0.8792	More...
P17568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	ITCH	26:29	PPDY	ITCH,NEDD4	0.9726	More...
Q8WY41	Nanos homolog 1	ITCH	102:105	PPDY	ITCH,NEDD4	0.9214	More...
Q8N2Q7	Neuroligin-1	ITCH	799:802	PPDY	ITCH,NEDD4	0.9681	More...
Q8NFZ4	Neuroligin-2	ITCH	766:769	PPDY	ITCH,NEDD4	0.9784	More...
Q8N0W4	Neuroligin-4, X-linked	ITCH	757:760	PPDY	ITCH,NEDD4	0.9948	More...

Showing 1 to 25 of 48 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPDY

Degron related mutations and impact score

Drug responses associated with HNRNPR mutations

All proteins holding degron of PPDY