DegronMD - P08151(GLI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S453F	TCGA-06-0879	GBM	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0833
p.G863R	TCGA-17-Z022	LUAD	TCGA	PPDY	ITCH	869:872	Mutation rewiring degron network	0.1667
p.Y865C	TCGA-43-8118	LUSC	TCGA	PPDY	ITCH	869:872	Mutation rewiring degron network	0.2222
p.G469C	TCGA-86-7701	LUAD	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.3056
p.T461I	TCGA-AP-A1DK	UCEC	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.3056
p.T475S	TCGA-CF-A47V	BLCA	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.1389
p.D477Y	TCGA-EO-A22R	UCEC	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0833
p.D477Y	TCGA-F5-6814	READ	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0833
p.G472E	TCGA-FW-A3R5	SKCM	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.2222
p.P864H	TCGA-NK-A5CR	LUSC	TCGA	PPDY	ITCH	869:872	Mutation rewiring degron network	0.1944
p.P864H	DO219207	LUSC	ICGC	PPDY	ITCH	869:872	Mutation rewiring degron network	0.1944
p.T473N	DO1123	BRCA	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.1944
p.R462W	DO15951	HNSC	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation altering degron motif	0.8634
p.R462W	DO219481	SKCM	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation altering degron motif	0.8634
p.R464K	DO228945	LICA	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation altering degron motif	0.7237
p.S721F	DO37432	SKCM	ICGC	LNPYMD	LIG_APCC_ABBA_1	718:723	Mutation altering degron motif	0.7982
p.P709H	DO51236	SKCM	ICGC	LNPYMD	LIG_APCC_ABBA_1	718:723	Mutation rewiring degron network	0.0833
p.R462L	DO41752	UCEC	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation altering degron motif	0.8428
p.K875T	DO41903	UCEC	ICGC	PPDY	ITCH	869:872	Mutation rewiring degron network	0.25
p.L478F	SIDM00097	Breast Carcinoma	GDSC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0556
p.L478F	ACH-000147	Breast Cancer	CCLE	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0556
p.L478F	T47D	breast	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0556
p.G873D	HCT-15	large intestine	COSMIC	PPDY	ITCH	869:872	Mutation rewiring degron network	0.3056
p.H458Q	CPC-N	lung	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.2222
p.R456H	Sarc9371	bone	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.1667
p.R456S	SW1271	lung	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.1667
p.G472C	HEL	haematopoietic and lymphoid tissue	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.2222
p.T453N	NCI-H660	prostate	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	462:468	Mutation rewiring degron network	0.0833
p.A879T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	869:872	Mutation rewiring degron network	0.1389
p.P724L	KYSE-180	oesophagus	COSMIC	LNPYMD	LIG_APCC_ABBA_1	718:723	Mutation rewiring degron network	0.3056
p.P861L	23132-87	stomach	COSMIC	PPDY	ITCH	869:872	Mutation rewiring degron network	0.1111

Kaplan plot for GLI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLI1

UniProt ID: P08151

Entrez ID: 2735

Protein name: Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLI1 in