DegronMD

Uniprot ID: P08151

Source protein: Zinc finger protein GLI1

Source gene: GLI1

Class: DEG_SCF_TRCP1_1

Location: 462:468

E3 ligase: BTRC

DEGRON score: 0.9803

ASA_SCORE: 70.9857

COIL: 0.722

CONS_SCORE: 0.3753

DSS_SCORE: 0.6504

HELIX: 0.0614

FCONS_SCORE: 1.0064

RIG_SCORE: 0.6446

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S453F	TCGA-06-0879	GBM	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.0833
p.G469C	TCGA-86-7701	LUAD	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.3056
p.T461I	TCGA-AP-A1DK	UCEC	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.3056
p.T475S	TCGA-CF-A47V	BLCA	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.1389
p.D477Y	TCGA-EO-A22R	UCEC	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.0833
p.D477Y	TCGA-F5-6814	READ	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.0833
p.G472E	TCGA-FW-A3R5	SKCM	TCGA	DSGVEMT	DEG_SCF_TRCP1_1	0.2222
p.T473N	DO1123	BRCA	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	0.1944
p.R462W	DO15951	HNSC	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	0.8634
p.R462W	DO219481	SKCM	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	0.8634
p.R464K	DO228945	LICA	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	0.7237
p.R462L	DO41752	UCEC	ICGC	DSGVEMT	DEG_SCF_TRCP1_1	0.8428
p.L478F	SIDM00097	Breast Carcinoma	GDSC	DSGVEMT	DEG_SCF_TRCP1_1	0.0556
p.L478F	ACH-000147	Breast Cancer	CCLE	DSGVEMT	DEG_SCF_TRCP1_1	0.0556
p.L478F	T47D	breast	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	0.0556
p.H458Q	CPC-N	lung	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	0.2222
p.R456H	Sarc9371	bone	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	0.1667
p.R456S	SW1271	lung	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	0.1667
p.G472C	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	0.2222
p.T453N	NCI-H660	prostate	COSMIC	DSGVEMT	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08151	Zinc finger protein GLI1	DEG_SCF_TRCP1_1	462:468	DSGVEMT	BTRC	0.9803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons