DegronMD

Uniprot ID: P08151

Source protein: Zinc finger protein GLI1

Source gene: GLI1

Class: LIG_APCC_ABBA_1

Location: 718:723

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9111

ASA_SCORE: 73.4667

COIL: 0.8478

CONS_SCORE: 0.3822

DSS_SCORE: 0.5349

HELIX: 0.1008

FCONS_SCORE: 1.0331

RIG_SCORE: 0.7008

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S721F	DO37432	SKCM	ICGC	LNPYMD	LIG_APCC_ABBA_1	0.7982
p.P709H	DO51236	SKCM	ICGC	LNPYMD	LIG_APCC_ABBA_1	0.0833
p.P724L	KYSE-180	oesophagus	COSMIC	LNPYMD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08151	Zinc finger protein GLI1	LIG_APCC_ABBA_1	718:723	LNPYMD	APC,CDC20,FZR1	0.9111	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons