DegronMD - Q96JB1(DNAH8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E4240D	TCGA-17-Z045	LUAD	TCGA	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.2222
p.E4226A	TCGA-AG-3725	READ	TCGA	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1389
p.E4240K	TCGA-D3-A8GO	SKCM	TCGA	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.2222
p.E4226K	TCGA-E6-A1M0	UCEC	TCGA	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1389
p.E4226K	DO220877	MELA	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1389
p.E4226K	DO43682	UCEC	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1389
p.S4243Y	TCGA-EO-A22X	UCEC	TCGA	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1389
p.R4228T	DO8946	COAD	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.R4237C	DO229480	LAML	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.3056
p.S4241I	DO229028	LICA	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.E4225K	DO229050	LICA	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1111
p.R4228G	DO51193	LUAD	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.I4235V	DO230990	LUSC	ICGC	PPDY	ITCH	4233:4236	Mutation altering degron motif	0.7076
p.I4235V	DO231007	LUSC	ICGC	PPDY	ITCH	4233:4236	Mutation altering degron motif	0.7076
p.I4235T	DO26862	LUSC	ICGC	PPDY	ITCH	4233:4236	Mutation altering degron motif	0.7078
p.R4228K	DO219165	LUSC	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.R4228K	DO223910	SKCM	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.S4234L	DO222702	MELA	ICGC	PPDY	ITCH	4233:4236	Mutation altering degron motif	0.7667
p.Q4224H	DO223286	UCEC	ICGC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.0833
p.A4241T	SIDM00212	Glioblastoma	GDSC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.A4241T	SIDM01107	Melanoma	GDSC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.A4241T	SK-MEL-1	skin	COSMIC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.A4241T	CAS-1	central nervous system	COSMIC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.1944
p.P4234S	ACH-000309	Lung Cancer	CCLE	PPDY	ITCH	4233:4236	Mutation altering degron motif	0.6752
p.P4234S	SK-LU-1	lung	COSMIC	PPDY	ITCH	4233:4236	Mutation altering degron motif	0.6752
p.L4229M	ACH-000869	Lung Cancer	CCLE	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.2222
p.L4229M	NCI-H1568	lung	COSMIC	PPDY	ITCH	4233:4236	Mutation rewiring degron network	0.2222

Kaplan plot for DNAH8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH8

UniProt ID: Q96JB1

Entrez ID: 1769

Protein name: Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH8 in