DegronMD

Uniprot ID: P20810

Source protein: Calpastatin

Source gene: CAST

Class: DEG_SPOP_SBC_1

Location: 185:189

E3 ligase: SPOP

DEGRON score: 0.9644

ASA_SCORE: 82.9

COIL: 0.8576

CONS_SCORE: 0.6071

DSS_SCORE: 0.6064

HELIX: 0.101

FCONS_SCORE: 0.865

RIG_SCORE: 0.7086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D187Y	TCGA-62-A46O	LUAD	TCGA	PMSST	DEG_SPOP_SBC_1	0.7325
p.S193L	TCGA-99-8025	LUAD	TCGA	PMSST	DEG_SPOP_SBC_1	0.2222
p.S184Y	TCGA-B5-A1MR	UCEC	TCGA	PMSST	DEG_SPOP_SBC_1	0.3056
p.P178T	TCGA-DA-A1I1	SKCM	TCGA	PMSST	DEG_SPOP_SBC_1	0.1389
p.T177N	TCGA-EY-A1G8	UCEC	TCGA	PMSST	DEG_SPOP_SBC_1	0.1111
p.E177D	DO223732	CESC	ICGC	PMSST	DEG_SPOP_SBC_1	0.1111
p.E177D	DO36556	READ	ICGC	PMSST	DEG_SPOP_SBC_1	0.1111
p.V197F	DO228971	LICA	ICGC	PMSST	DEG_SPOP_SBC_1	0.1111
p.P186Q	DO37738	SKCM	ICGC	PMSST	DEG_SPOP_SBC_1	0.7035
p.M186V	ACH-000047	Gastric Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	0.6097
p.M186V	GCIY	stomach	COSMIC	PMSST	DEG_SPOP_SBC_1	0.6097
p.E199V	ACH-000671	Liver Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	0.0556
p.E199V	ACH-002395	Liver Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	0.0556
p.E199V	HUH-6-clone5	liver	COSMIC	PMSST	DEG_SPOP_SBC_1	0.0556
p.R182L	ACH-000994	Endometrial/Uterine Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	0.25
p.R197K	ACH-002300	Lymphoma	CCLE	PMSST	DEG_SPOP_SBC_1	0.1111
p.R197K	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	0.1111
p.A196V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	0.25
p.R183K	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	0.7222
p.A188V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	0.6936
p.S196I	NB5	autonomic_ganglia	COSMIC	PMSST	DEG_SPOP_SBC_1	0.25
p.A193T	SNU-1040	large_intestine	COSMIC	PMSST	DEG_SPOP_SBC_1	0.2222
p.R175K	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	0.0556
p.K182N	FTC-133	thyroid	COSMIC	PMSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20810	Calpastatin	DEG_SPOP_SBC_1	185:189	PMSST	SPOP	0.9644	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMSST

Degron related mutations and impact score

Drug responses associated with CAST mutations

All proteins holding degron of PMSST