DegronMD

Uniprot ID: P20810

Source protein: Calpastatin

Source gene: CAST

Class: ITCH

Location: 202:205

E3 ligase: ITCH,NEDD4

DEGRON score: 0.937

ASA_SCORE: 84.55

COIL: 0.5848

CONS_SCORE: 0.8094

DSS_SCORE: 0.4632

HELIX: 0.3935

FCONS_SCORE: 1.2702

RIG_SCORE: 0.7931

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S193L	TCGA-99-8025	LUAD	TCGA	PPKY	ITCH	0.0833
p.T205N	TCGA-AX-A0J0	UCEC	TCGA	PPKY	ITCH	0.7055
p.G205R	DO224700	BRCA	ICGC	PPKY	ITCH	0.7568
p.S204F	DO49962	CESC	ICGC	PPKY	ITCH	0.7982
p.S204F	DO47997	STAD	ICGC	PPKY	ITCH	0.7982
p.K214N	DO7801	COAD	ICGC	PPKY	ITCH	0.0833
p.K214N	DO52412	UCEC	ICGC	PPKY	ITCH	0.0833
p.E213K	DO228963	LICA	ICGC	PPKY	ITCH	0.1111
p.V197F	DO228971	LICA	ICGC	PPKY	ITCH	0.1944
p.P207L	DO42568	UCEC	ICGC	PPKY	ITCH	0.2778
p.E202D	SIDM00899	Pancreatic Carcinoma	GDSC	PPKY	ITCH	0.6758
p.E199V	ACH-000671	Liver Cancer	CCLE	PPKY	ITCH	0.25
p.E199V	ACH-002395	Liver Cancer	CCLE	PPKY	ITCH	0.25
p.E199V	HUH-6-clone5	liver	COSMIC	PPKY	ITCH	0.25
p.R197K	ACH-002300	Lymphoma	CCLE	PPKY	ITCH	0.1944
p.R197K	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PPKY	ITCH	0.1944
p.A196V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPKY	ITCH	0.2778
p.K206N	HCC2998	large_intestine	COSMIC	PPKY	ITCH	0.3056
p.E207V	HUH-6-clone5	liver	COSMIC	PPKY	ITCH	0.2778
p.S196I	NB5	autonomic_ganglia	COSMIC	PPKY	ITCH	0.2778
p.A210V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPKY	ITCH	0.1944
p.A193T	SNU-1040	large_intestine	COSMIC	PPKY	ITCH	0.0833

Drug responses associated with CAST mutations

All proteins holding degron of PPKY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	ITCH	1284:1287	PPKY	ITCH,NEDD4	0.7887	More...
P20810	Calpastatin	ITCH	202:205	PPKY	ITCH,NEDD4	0.937	More...
P29144	Tripeptidyl-peptidase 2	ITCH	942:945	PPKY	ITCH,NEDD4	0.8785	More...
P51170	Amiloride-sensitive sodium channel subunit gamma	ITCH	624:627	PPKY	ITCH,NEDD4	0.9353	More...
P54259	Atrophin-1	ITCH	424:427	PPKY	ITCH,NEDD4	0.9876	More...
Q00688	Peptidyl-prolyl cis-trans isomerase FKBP3	ITCH	108:111	PPKY	ITCH,NEDD4	0.9478	More...
Q06190	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha	ITCH	331:334	PPKY	ITCH,NEDD4	0.9998	More...
Q08174	Protocadherin-1	ITCH	1026:1029	PPKY	ITCH,NEDD4	0.9976	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	ITCH	1526:1529	PPKY	ITCH,NEDD4	0.9925	More...
Q8N6H7	ADP-ribosylation factor GTPase-activating protein 2	ITCH	355:358	PPKY	ITCH,NEDD4	0.9993	More...
Q8WWU5	T-complex protein 11 homolog	ITCH	9:12	PPKY	ITCH,NEDD4	0.9918	More...
Q8WZ42	Titin	ITCH	23191:23194	PPKY	ITCH,NEDD4	0.7018	More...
Q8WZ42	Titin	ITCH	27520:27523	PPKY	ITCH,NEDD4	0.6774	More...
Q96B18	Dapper homolog 3	ITCH	441:444	PPKY	ITCH,NEDD4	0.9495	More...
Q96BD5	PHD finger protein 21A	ITCH	431:434	PPKY	ITCH,NEDD4	0.9794	More...
Q9UBL6	Copine-7	ITCH	443:446	PPKY	ITCH,NEDD4	0.6593	More...
Q9UPG8	Zinc finger protein PLAGL2	ITCH	339:342	PPKY	ITCH,NEDD4	0.8841	More...
Q9Y2I6	Ninein-like protein	ITCH	99:102	PPKY	ITCH,NEDD4	0.5986	More...
Q9Y696	Chloride intracellular channel protein 4	ITCH	101:104	PPKY	ITCH,NEDD4	0.8903	More...
Q9BZD7	Transmembrane gamma-carboxyglutamic acid protein 3	ITCH	216:219	PPKY	ITCH,NEDD4	0.9823	More...
A8K0R7	Zinc finger protein 839	ITCH	140:143	PPKY	ITCH,NEDD4	0.8006	More...
Q2M218	Zinc finger protein 630	ITCH	212:215	PPKY	ITCH,NEDD4	0.5506	More...
Q5SZD1	Uncharacterized protein C6orf141	ITCH	154:157	PPKY	ITCH,NEDD4	0.7621	More...
Q8NDZ0	BEN domain-containing protein 2	ITCH	473:476	PPKY	ITCH,NEDD4	0.9633	More...
Q0VF49	Uncharacterized protein KIAA2012	ITCH	206:209	PPKY	ITCH,NEDD4	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPKY

Degron related mutations and impact score

Drug responses associated with CAST mutations

All proteins holding degron of PPKY