DegronMD - Q9Y2I6(NINL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R583Q	TCGA-59-2349	OV	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.0556
p.R583Q	DO28621	OV	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.0556
p.R593C	TCGA-63-A5MM	LUSC	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.719
p.R593C	DO219153	LUSC	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.719
p.R593C	DO35442	PACA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.719
p.R112W	TCGA-AP-A0LM	UCEC	TCGA	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.R112W	DO43306	UCEC	ICGC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.K101T	TCGA-BR-4257	STAD	TCGA	PPKY	ITCH	99:102	Mutation altering degron motif	0.6195
p.K101T	DO38683	STAD	ICGC	PPKY	ITCH	99:102	Mutation altering degron motif	0.6195
p.K101T	SIDM00216	Colorectal Carcinoma	GDSC	PPKY	ITCH	99:102	Mutation altering degron motif	0.6195
p.K101T	ACH-000989	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	99:102	Mutation altering degron motif	0.6195
p.K101T	SNU-175	large intestine	COSMIC	PPKY	ITCH	99:102	Mutation altering degron motif	0.6195
p.S89F	TCGA-D6-6516	HNSC	TCGA	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.S89F	TCGA-D9-A1JW	SKCM	TCGA	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.S89F	DO15623	HNSC	ICGC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.S89F	DO37786	SKCM	ICGC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.A93S	TCGA-ER-A19D	SKCM	TCGA	PPKY	ITCH	99:102	Mutation rewiring degron network	0.1667
p.A93S	DO37750	SKCM	ICGC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.1667
p.H584L	TCGA-FA-A82F	DLBC	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.0833
p.H584L	DO219891	DLBC	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.0833
p.R111C	TCGA-G4-6320	COAD	TCGA	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0833
p.R111C	DO8159	COAD	ICGC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0833
p.R595Q	TCGA-HF-A5NB	STAD	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.6218
p.R595Q	DO50127	STAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.6218
p.G601S	TCGA-SW-A7EA	STAD	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.5882
p.G601S	DO51749	STAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.5882
p.H584Y	DO50452	ESAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.0833
p.W588R	DO234320	ESAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.1944
p.R112Q	DO233864	GACA	ICGC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.R112Q	SIDM00677	Colorectal Carcinoma	GDSC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0556
p.P602T	DO228976	LICA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.3056
p.R593S	DO229009	LICA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation altering degron motif	0.6316
p.S606L	DO220857	MELA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.1944
p.P586L	DO220861	MELA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.1389
p.P100L	DO222875	MELA	ICGC	PPKY	ITCH	99:102	Mutation altering degron motif	0.7582
p.A603S	DO50707	ORCA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.2778
p.G604C	DO229272	THCA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation rewiring degron network	0.25
p.S585C	DO229221	THCA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	593:601	Mutation blocking phosphorylation signal	0.5556
p.R111H	SIDM00602	Gastric Carcinoma	GDSC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0833
p.R111H	ACH-000919	Gastric Cancer	CCLE	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0833
p.R111H	IM-95	stomach	COSMIC	PPKY	ITCH	99:102	Mutation rewiring degron network	0.0833

Kaplan plot for NINL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NINL

UniProt ID: Q9Y2I6

Entrez ID: 22981

Protein name: Ninein-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NINL in