DegronMD

Uniprot ID: Q9Y2I6

Source protein: Ninein-like protein

Source gene: NINL

Class: DEG_APCC_DBOX_1

Location: 593:601

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9712

ASA_SCORE: 98.4778

COIL: 0.7682

CONS_SCORE: 0.732

DSS_SCORE: 0.5449

HELIX: 0.1572

FCONS_SCORE: 1.0261

RIG_SCORE: 0.641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R583Q	TCGA-59-2349	OV	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	0.0556
p.R583Q	DO28621	OV	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.0556
p.R593C	TCGA-63-A5MM	LUSC	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	0.719
p.R593C	DO219153	LUSC	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.719
p.R593C	DO35442	PACA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.719
p.H584L	TCGA-FA-A82F	DLBC	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	0.0833
p.H584L	DO219891	DLBC	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.0833
p.R595Q	TCGA-HF-A5NB	STAD	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	0.6218
p.R595Q	DO50127	STAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.6218
p.G601S	TCGA-SW-A7EA	STAD	TCGA	RRRQLPGLG	DEG_APCC_DBOX_1	0.5882
p.G601S	DO51749	STAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.5882
p.H584Y	DO50452	ESAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.0833
p.W588R	DO234320	ESAD	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.1944
p.P602T	DO228976	LICA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.3056
p.R593S	DO229009	LICA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.6316
p.S606L	DO220857	MELA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.1944
p.P586L	DO220861	MELA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.1389
p.A603S	DO50707	ORCA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.2778
p.G604C	DO229272	THCA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.25
p.S585C	DO229221	THCA	ICGC	RRRQLPGLG	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I6	Ninein-like protein	DEG_APCC_DBOX_1	593:601	RRRQLPGLG	APC,CDC20,FZR1	0.9712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons