DegronMD - Q8NDZ0(BEND2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V276L	TCGA-13-0920	OV	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation altering degron motif	0.5654
p.V276L	DO28099	OV	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation altering degron motif	0.5654
p.R264L	TCGA-44-7670	LUAD	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1111
p.R264L	DO23555	LUAD	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1111
p.S461I	TCGA-55-A494	LUAD	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation altering degron motif	0.7341
p.S461I	DO23794	LUAD	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation altering degron motif	0.7341
p.M451I	TCGA-A5-A0G2	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.0833
p.M451I	TCGA-AJ-A3EL	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.0833
p.M451I	DO41542	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.0833
p.M451I	DO41235	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.0833
p.R453H	TCGA-AA-3984	COAD	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453H	DO9002	COAD	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453H	SIDM00534	Colorectal Carcinoma	GDSC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453H	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453H	HT-115	large intestine	COSMIC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453C	TCGA-AC-A23H	BRCA	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453C	TCGA-AJ-A5DW	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453C	DO2401	BRCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453C	DO229459	SKCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.R453C	DO50075	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.S469Y	TCGA-AX-A2HC	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.25
p.S469Y	TCGA-AX-A2HC	UCEC	TCGA	PPKY	ITCH	473:476	Mutation rewiring degron network	0.2222
p.S469Y	DO41572	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.25
p.S469Y	DO41572	UCEC	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.2222
p.R484K	TCGA-AZ-4315	COAD	TCGA	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1111
p.R484K	DO8842	COAD	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1111
p.S469C	TCGA-BT-A42E	BLCA	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.25
p.S469C	TCGA-BT-A42E	BLCA	TCGA	PPKY	ITCH	473:476	Mutation rewiring degron network	0.2222
p.S469C	DO44030	BLCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.25
p.S469C	DO44030	BLCA	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.2222
p.P289T	TCGA-CR-7388	HNSC	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1389
p.P289T	DO14284	HNSC	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1389
p.A292D	TCGA-CS-5390	LGG	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.0556
p.A292D	DO22688	LGG	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.0556
p.P482S	TCGA-CV-5979	HNSC	TCGA	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1667
p.P482S	DO14178	HNSC	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1667
p.A292T	TCGA-EE-A2MR	SKCM	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.0556
p.A292T	DO37819	SKCM	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.0556
p.R484I	TCGA-F5-6814	READ	TCGA	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1111
p.R484I	DO36556	READ	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1111
p.R264Q	TCGA-HR-A2OH	SKCM	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1111
p.R264Q	DO37774	SKCM	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1111
p.N286D	TCGA-KQ-A41R	BLCA	TCGA	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.2222
p.N286D	DO223592	BLCA	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.2222
p.L457S	DO10172	COAD	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.25
p.R453S	DO229038	LICA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.1389
p.N271S	DO229101	LMS	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.3056
p.P282R	DO52666	MALY	ICGC	NPGVVNYSALP	CBL_PTK	272:282	Mutation altering degron motif	0.7512
p.D481N	DO220857	MELA	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.1944
p.G462D	DO228138	PBCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation altering degron motif	0.7198
p.V486F	DO229213	THCA	ICGC	PPKY	ITCH	473:476	Mutation rewiring degron network	0.0556
p.A280S	SIDM00197	Ewing's Sarcoma	GDSC	NPGVVNYSALP	CBL_PTK	272:282	Mutation altering degron motif	0.6477
p.A280S	ACH-002115	Bone Cancer	CCLE	NPGVVNYSALP	CBL_PTK	272:282	Mutation altering degron motif	0.6477
p.A280S	EW-18	bone	COSMIC	NPGVVNYSALP	CBL_PTK	272:282	Mutation altering degron motif	0.6477
p.V287M	SIDM01019	Acute Myeloid Leukemia	GDSC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1944
p.V287M	ACH-002258	Leukemia	CCLE	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1944
p.V287M	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	NPGVVNYSALP	CBL_PTK	272:282	Mutation rewiring degron network	0.1944
p.A456V	SNU-1040	large intestine	COSMIC	DSGQDSS	DEG_SCF_TRCP1_1	460:466	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BEND2

UniProt ID: Q8NDZ0

Entrez ID: 139105

Protein name: BEN domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BEND2 in