DegronMD

Uniprot ID: Q8NDZ0

Source protein: BEN domain-containing protein 2

Source gene: BEND2

Class: CBL_PTK

Location: 272:282

E3 ligase: CBL

DEGRON score: 0.9925

ASA_SCORE: 57.0636

COIL: 0.7276

CONS_SCORE: 0.3838

DSS_SCORE: 0.4018

HELIX: 0.0958

FCONS_SCORE: 1.0658

RIG_SCORE: 0.7207

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V276L	TCGA-13-0920	OV	TCGA	NPGVVNYSALP	CBL_PTK	0.5654
p.V276L	DO28099	OV	ICGC	NPGVVNYSALP	CBL_PTK	0.5654
p.R264L	TCGA-44-7670	LUAD	TCGA	NPGVVNYSALP	CBL_PTK	0.1111
p.R264L	DO23555	LUAD	ICGC	NPGVVNYSALP	CBL_PTK	0.1111
p.P289T	TCGA-CR-7388	HNSC	TCGA	NPGVVNYSALP	CBL_PTK	0.1389
p.P289T	DO14284	HNSC	ICGC	NPGVVNYSALP	CBL_PTK	0.1389
p.A292D	TCGA-CS-5390	LGG	TCGA	NPGVVNYSALP	CBL_PTK	0.0556
p.A292D	DO22688	LGG	ICGC	NPGVVNYSALP	CBL_PTK	0.0556
p.A292T	TCGA-EE-A2MR	SKCM	TCGA	NPGVVNYSALP	CBL_PTK	0.0556
p.A292T	DO37819	SKCM	ICGC	NPGVVNYSALP	CBL_PTK	0.0556
p.R264Q	TCGA-HR-A2OH	SKCM	TCGA	NPGVVNYSALP	CBL_PTK	0.1111
p.R264Q	DO37774	SKCM	ICGC	NPGVVNYSALP	CBL_PTK	0.1111
p.N286D	TCGA-KQ-A41R	BLCA	TCGA	NPGVVNYSALP	CBL_PTK	0.2222
p.N286D	DO223592	BLCA	ICGC	NPGVVNYSALP	CBL_PTK	0.2222
p.N271S	DO229101	LMS	ICGC	NPGVVNYSALP	CBL_PTK	0.3056
p.P282R	DO52666	MALY	ICGC	NPGVVNYSALP	CBL_PTK	0.7512
p.A280S	SIDM00197	Ewing's Sarcoma	GDSC	NPGVVNYSALP	CBL_PTK	0.6477
p.A280S	ACH-002115	Bone Cancer	CCLE	NPGVVNYSALP	CBL_PTK	0.6477
p.A280S	EW-18	bone	COSMIC	NPGVVNYSALP	CBL_PTK	0.6477
p.V287M	SIDM01019	Acute Myeloid Leukemia	GDSC	NPGVVNYSALP	CBL_PTK	0.1944
p.V287M	ACH-002258	Leukemia	CCLE	NPGVVNYSALP	CBL_PTK	0.1944
p.V287M	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	NPGVVNYSALP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDZ0	BEN domain-containing protein 2	CBL_PTK	272:282	NPGVVNYSALP	CBL	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons