DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPKY
Uniprot ID:
Q8NDZ0
Source protein:
BEN domain-containing protein 2
Source gene:
BEND2
Class:
ITCH
Location:
473:476
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9633
ASA_SCORE:
86.4
COIL:
0.803
CONS_SCORE:
0.3427
DSS_SCORE:
0.4299
HELIX:
0.0252
FCONS_SCORE:
0.6416
RIG_SCORE:
0.7367
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S469Y
TCGA-AX-A2HC
UCEC
TCGA
PPKY
ITCH
0.2222
p.S469Y
DO41572
UCEC
ICGC
PPKY
ITCH
0.2222
p.S469C
TCGA-BT-A42E
BLCA
TCGA
PPKY
ITCH
0.2222
p.S469C
DO44030
BLCA
ICGC
PPKY
ITCH
0.2222
p.D481N
DO220857
MELA
ICGC
PPKY
ITCH
0.1944
p.P482S
TCGA-CV-5979
HNSC
TCGA
PPKY
ITCH
0.1667
p.P482S
DO14178
HNSC
ICGC
PPKY
ITCH
0.1667
p.R484K
TCGA-AZ-4315
COAD
TCGA
PPKY
ITCH
0.1111
p.R484K
DO8842
COAD
ICGC
PPKY
ITCH
0.1111
p.R484I
TCGA-F5-6814
READ
TCGA
PPKY
ITCH
0.1111
p.R484I
DO36556
READ
ICGC
PPKY
ITCH
0.1111
p.V486F
DO229213
THCA
ICGC
PPKY
ITCH
0.0556
Showing 1 to 12 of 12 entries
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Drug responses associated with BEND2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPKY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N6H7
ADP-ribosylation factor GTPase-activating protein 2
ITCH
355:358
PPKY
ITCH,NEDD4
0.9993
More...
P51170
Amiloride-sensitive sodium channel subunit gamma
ITCH
624:627
PPKY
ITCH,NEDD4
0.9353
More...
P54259
Atrophin-1
ITCH
424:427
PPKY
ITCH,NEDD4
0.9876
More...
Q8NDZ0
BEN domain-containing protein 2
ITCH
473:476
PPKY
ITCH,NEDD4
0.9633
More...
P20810
Calpastatin
ITCH
202:205
PPKY
ITCH,NEDD4
0.937
More...
Q9Y696
Chloride intracellular channel protein 4
ITCH
101:104
PPKY
ITCH,NEDD4
0.8903
More...
Q9UBL6
Copine-7
ITCH
443:446
PPKY
ITCH,NEDD4
0.6593
More...
Q96B18
Dapper homolog 3
ITCH
441:444
PPKY
ITCH,NEDD4
0.9495
More...
Q71F56
Mediator of RNA polymerase II transcription subunit 13-like
ITCH
1526:1529
PPKY
ITCH,NEDD4
0.9925
More...
Q9Y2I6
Ninein-like protein
ITCH
99:102
PPKY
ITCH,NEDD4
0.5986
More...
Q00688
Peptidyl-prolyl cis-trans isomerase FKBP3
ITCH
108:111
PPKY
ITCH,NEDD4
0.9478
More...
Q96BD5
PHD finger protein 21A
ITCH
431:434
PPKY
ITCH,NEDD4
0.9794
More...
O94964
Protein SOGA1
ITCH
1284:1287
PPKY
ITCH,NEDD4
0.7887
More...
Q08174
Protocadherin-1
ITCH
1026:1029
PPKY
ITCH,NEDD4
0.9976
More...
Q06190
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
ITCH
331:334
PPKY
ITCH,NEDD4
0.9998
More...
Q8WWU5
T-complex protein 11 homolog
ITCH
9:12
PPKY
ITCH,NEDD4
0.9918
More...
Q8WZ42
Titin
ITCH
23191:23194
PPKY
ITCH,NEDD4
0.7018
More...
Q8WZ42
Titin
ITCH
27520:27523
PPKY
ITCH,NEDD4
0.6774
More...
Q9BZD7
Transmembrane gamma-carboxyglutamic acid protein 3
ITCH
216:219
PPKY
ITCH,NEDD4
0.9823
More...
P29144
Tripeptidyl-peptidase 2
ITCH
942:945
PPKY
ITCH,NEDD4
0.8785
More...
Q5SZD1
Uncharacterized protein C6orf141
ITCH
154:157
PPKY
ITCH,NEDD4
0.7621
More...
Q0VF49
Uncharacterized protein KIAA2012
ITCH
206:209
PPKY
ITCH,NEDD4
0.9964
More...
Q2M218
Zinc finger protein 630
ITCH
212:215
PPKY
ITCH,NEDD4
0.5506
More...
A8K0R7
Zinc finger protein 839
ITCH
140:143
PPKY
ITCH,NEDD4
0.8006
More...
Q9UPG8
Zinc finger protein PLAGL2
ITCH
339:342
PPKY
ITCH,NEDD4
0.8841
More...
Showing 1 to 25 of 25 entries
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