DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: ITCH

Location: 23191:23194

E3 ligase: ITCH,NEDD4

DEGRON score: 0.7018

ASA_SCORE: 92.65

COIL: 0.8965

CONS_SCORE: 0.5238

DSS_SCORE: 0.3778

HELIX: 0.0695

FCONS_SCORE: 0.9022

RIG_SCORE: 0.7105

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V23194D	TCGA-34-2596	LUSC	TCGA	PPKY	ITCH	0.7785
p.K23200N	TCGA-49-6743	LUAD	TCGA	PPKY	ITCH	0.1667
p.A23189V	TCGA-66-2770	LUSC	TCGA	PPKY	ITCH	0.2778
p.R23185Q	TCGA-77-7337	LUSC	TCGA	PPKY	ITCH	0.1667
p.R23185Q	TCGA-CG-5726	STAD	TCGA	PPKY	ITCH	0.1667
p.R23185Q	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	PPKY	ITCH	0.1667
p.R23185Q	NB(TU)1-10	autonomic_ganglia	COSMIC	PPKY	ITCH	0.1667
p.S23183N	TCGA-BH-A0HF	BRCA	TCGA	PPKY	ITCH	0.1111
p.G23203R	TCGA-DX-AB2E	SARC	TCGA	PPKY	ITCH	0.0833
p.G23203E	TCGA-FW-A3R5	SKCM	TCGA	PPKY	ITCH	0.0833
p.K23200R	TCGA-KU-A66S	HNSC	TCGA	PPKY	ITCH	0.1667
p.K23181N	TCGA-ND-A4WC	UCS	TCGA	PPKY	ITCH	0.0556
p.D23183N	DO44377	CESC	ICGC	PPKY	ITCH	0.1111
p.A23182V	DO8103	COAD	ICGC	PPKY	ITCH	0.0833
p.S23199Y	DO222884	COCA	ICGC	PPKY	ITCH	0.6389
p.P23191T	DO23708	LUAD	ICGC	PPKY	ITCH	0.7031
p.P23192H	DO26250	LUAD	ICGC	PPKY	ITCH	0.7694
p.S23188F	DO220906	MELA	ICGC	PPKY	ITCH	0.25
p.S23188F	DO37831	SKCM	ICGC	PPKY	ITCH	0.25
p.N23202I	DO47359	SKCM	ICGC	PPKY	ITCH	0.1111
p.I23190T	SIDM00845	Burkitt's Lymphoma	GDSC	PPKY	ITCH	0.3056
p.G23190V	Ca-Ski	cervix	COSMIC	PPKY	ITCH	0.3056
p.G23194R	Mewo	skin	COSMIC	PPKY	ITCH	0.7568
p.R23204W	SNU-81	large_intestine	COSMIC	PPKY	ITCH	0.0556
p.P23189T	NCI-H2009	lung	COSMIC	PPKY	ITCH	0.2778
p.Y23194C	HCC1569	breast	COSMIC	PPKY	ITCH	0.7087
p.R23185W	LoVo	large_intestine	COSMIC	PPKY	ITCH	0.1667

Drug responses associated with TTN mutations

All proteins holding degron of PPKY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	ITCH	1284:1287	PPKY	ITCH,NEDD4	0.7887	More...
P20810	Calpastatin	ITCH	202:205	PPKY	ITCH,NEDD4	0.937	More...
P29144	Tripeptidyl-peptidase 2	ITCH	942:945	PPKY	ITCH,NEDD4	0.8785	More...
P51170	Amiloride-sensitive sodium channel subunit gamma	ITCH	624:627	PPKY	ITCH,NEDD4	0.9353	More...
P54259	Atrophin-1	ITCH	424:427	PPKY	ITCH,NEDD4	0.9876	More...
Q00688	Peptidyl-prolyl cis-trans isomerase FKBP3	ITCH	108:111	PPKY	ITCH,NEDD4	0.9478	More...
Q06190	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha	ITCH	331:334	PPKY	ITCH,NEDD4	0.9998	More...
Q08174	Protocadherin-1	ITCH	1026:1029	PPKY	ITCH,NEDD4	0.9976	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	ITCH	1526:1529	PPKY	ITCH,NEDD4	0.9925	More...
Q8N6H7	ADP-ribosylation factor GTPase-activating protein 2	ITCH	355:358	PPKY	ITCH,NEDD4	0.9993	More...
Q8WWU5	T-complex protein 11 homolog	ITCH	9:12	PPKY	ITCH,NEDD4	0.9918	More...
Q8WZ42	Titin	ITCH	23191:23194	PPKY	ITCH,NEDD4	0.7018	More...
Q8WZ42	Titin	ITCH	27520:27523	PPKY	ITCH,NEDD4	0.6774	More...
Q96B18	Dapper homolog 3	ITCH	441:444	PPKY	ITCH,NEDD4	0.9495	More...
Q96BD5	PHD finger protein 21A	ITCH	431:434	PPKY	ITCH,NEDD4	0.9794	More...
Q9UBL6	Copine-7	ITCH	443:446	PPKY	ITCH,NEDD4	0.6593	More...
Q9UPG8	Zinc finger protein PLAGL2	ITCH	339:342	PPKY	ITCH,NEDD4	0.8841	More...
Q9Y2I6	Ninein-like protein	ITCH	99:102	PPKY	ITCH,NEDD4	0.5986	More...
Q9Y696	Chloride intracellular channel protein 4	ITCH	101:104	PPKY	ITCH,NEDD4	0.8903	More...
Q9BZD7	Transmembrane gamma-carboxyglutamic acid protein 3	ITCH	216:219	PPKY	ITCH,NEDD4	0.9823	More...
A8K0R7	Zinc finger protein 839	ITCH	140:143	PPKY	ITCH,NEDD4	0.8006	More...
Q2M218	Zinc finger protein 630	ITCH	212:215	PPKY	ITCH,NEDD4	0.5506	More...
Q5SZD1	Uncharacterized protein C6orf141	ITCH	154:157	PPKY	ITCH,NEDD4	0.7621	More...
Q8NDZ0	BEN domain-containing protein 2	ITCH	473:476	PPKY	ITCH,NEDD4	0.9633	More...
Q0VF49	Uncharacterized protein KIAA2012	ITCH	206:209	PPKY	ITCH,NEDD4	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPKY

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of PPKY