DegronMD - A8K0R7(ZNF839)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131N	TCGA-AP-A1DV	UCEC	TCGA	PPKY	ITCH	140:143	Mutation substituting flanking lysine	0.1944
p.S131N	DO43186	UCEC	ICGC	PPKY	ITCH	140:143	Mutation substituting flanking lysine	0.1944
p.E460V	TCGA-CI-6624	READ	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.2222
p.E460V	DO37130	READ	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.2222
p.Q444R	TCGA-CK-5916	COAD	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.1667
p.Q444R	DO8786	COAD	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.1667
p.A441V	TCGA-EO-A3KX	UCEC	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.0833
p.A146T	TCGA-IB-7651	PAAD	TCGA	PPKY	ITCH	140:143	Mutation substituting flanking lysine	0.3611
p.A146T	DO46657	PAAD	ICGC	PPKY	ITCH	140:143	Mutation substituting flanking lysine	0.3611
p.S464L	TCGA-LP-A4AV	CESC	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.1111
p.Q444H	DO229036	LICA	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.1667
p.E452K	DO51291	SKCM	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation altering degron motif	0.591
p.A457V	SIDM01722	Non-Cancerous	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.3056
p.A457V	SIDM00174	Head and Neck Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.3056
p.A457V	SIDM00803	Kidney Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.3056
p.A463V	SIDM00980	Gastric Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.1389
p.A463V	23132-87	stomach	COSMIC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.1389
p.T440A	SIDM00785	Acute Myeloid Leukemia	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.0556
p.T440A	KG-1	haematopoietic and lymphoid tissue	COSMIC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.0556
p.G454S	SIDM00497	Colorectal Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation altering degron motif	0.6993
p.R136Q	ACH-000804	Neuroblastoma	CCLE	PPKY	ITCH	140:143	Mutation rewiring degron network	0.2222
p.R136Q	NB1	autonomic ganglia	COSMIC	PPKY	ITCH	140:143	Mutation rewiring degron network	0.2222
p.R465Q	SNU-C2B	large intestine	COSMIC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	450:456	Mutation rewiring degron network	0.0833
p.R133C	SNU-1040	large intestine	COSMIC	PPKY	ITCH	140:143	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF839

UniProt ID: A8K0R7

Entrez ID: 55778

Protein name: Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF839 in