DegronMD

Uniprot ID: A8K0R7

Source protein: Zinc finger protein 839

Source gene: ZNF839

Class: LIG_APCC_ABBAyCdc20_2

Location: 450:456

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7386

ASA_SCORE: 101.5

COIL: 0.6669

CONS_SCORE: 0.2386

DSS_SCORE: 0.4626

HELIX: 0.1123

FCONS_SCORE: 0.6406

RIG_SCORE: 0.7209

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E460V	TCGA-CI-6624	READ	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E460V	DO37130	READ	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q444R	TCGA-CK-5916	COAD	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q444R	DO8786	COAD	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A441V	TCGA-EO-A3KX	UCEC	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S464L	TCGA-LP-A4AV	CESC	TCGA	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q444H	DO229036	LICA	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E452K	DO51291	SKCM	ICGC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.591
p.A457V	SIDM01722	Non-Cancerous	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A457V	SIDM00174	Head and Neck Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A457V	SIDM00803	Kidney Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A463V	SIDM00980	Gastric Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A463V	23132-87	stomach	COSMIC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T440A	SIDM00785	Acute Myeloid Leukemia	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T440A	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G454S	SIDM00497	Colorectal Carcinoma	GDSC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.6993
p.R465Q	SNU-C2B	large_intestine	COSMIC	KKEIHPD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K0R7	Zinc finger protein 839	LIG_APCC_ABBAyCdc20_2	450:456	KKEIHPD	APC,CDC20,FZR1	0.7386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons