DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPKY
Uniprot ID:
Q9Y696
Source protein:
Chloride intracellular channel protein 4
Source gene:
CLIC4
Class:
ITCH
Location:
101:104
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.8903
ASA_SCORE:
91.975
COIL:
0.9153
CONS_SCORE:
0.3579
DSS_SCORE:
0.2773
HELIX:
0.044
FCONS_SCORE:
0.7722
RIG_SCORE:
0.8364
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L95I
TCGA-AG-A002
READ
TCGA
PPKY
ITCH
0.1667
p.L95I
SIDM00118
Colorectal Carcinoma
GDSC
PPKY
ITCH
0.1667
p.L95I
ACH-001081
Colon/Colorectal Cancer
CCLE
PPKY
ITCH
0.1667
p.L95I
HCC2998
large_intestine
COSMIC
PPKY
ITCH
0.1667
p.K103E
TCGA-E6-A1LX
UCEC
TCGA
PPKY
ITCH
0.591
p.K103E
DO41020
UCEC
ICGC
PPKY
ITCH
0.591
p.V98I
TCGA-NA-A4R1
UCS
TCGA
PPKY
ITCH
0.25
p.V98A
TCGA-UZ-A9PJ
KIRP
TCGA
PPKY
ITCH
0.25
p.V98A
DO219698
KIRP
ICGC
PPKY
ITCH
0.25
p.P102S
DO222696
MELA
ICGC
PPKY
ITCH
0.6752
p.V98F
DO50684
ORCA
ICGC
PPKY
ITCH
0.25
Drug responses associated with CLIC4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPKY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94964
Protein SOGA1
ITCH
1284:1287
PPKY
ITCH,NEDD4
0.7887
More...
P20810
Calpastatin
ITCH
202:205
PPKY
ITCH,NEDD4
0.937
More...
P29144
Tripeptidyl-peptidase 2
ITCH
942:945
PPKY
ITCH,NEDD4
0.8785
More...
P51170
Amiloride-sensitive sodium channel subunit gamma
ITCH
624:627
PPKY
ITCH,NEDD4
0.9353
More...
P54259
Atrophin-1
ITCH
424:427
PPKY
ITCH,NEDD4
0.9876
More...
Q00688
Peptidyl-prolyl cis-trans isomerase FKBP3
ITCH
108:111
PPKY
ITCH,NEDD4
0.9478
More...
Q06190
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
ITCH
331:334
PPKY
ITCH,NEDD4
0.9998
More...
Q08174
Protocadherin-1
ITCH
1026:1029
PPKY
ITCH,NEDD4
0.9976
More...
Q71F56
Mediator of RNA polymerase II transcription subunit 13-like
ITCH
1526:1529
PPKY
ITCH,NEDD4
0.9925
More...
Q8N6H7
ADP-ribosylation factor GTPase-activating protein 2
ITCH
355:358
PPKY
ITCH,NEDD4
0.9993
More...
Q8WWU5
T-complex protein 11 homolog
ITCH
9:12
PPKY
ITCH,NEDD4
0.9918
More...
Q8WZ42
Titin
ITCH
23191:23194
PPKY
ITCH,NEDD4
0.7018
More...
Q8WZ42
Titin
ITCH
27520:27523
PPKY
ITCH,NEDD4
0.6774
More...
Q96B18
Dapper homolog 3
ITCH
441:444
PPKY
ITCH,NEDD4
0.9495
More...
Q96BD5
PHD finger protein 21A
ITCH
431:434
PPKY
ITCH,NEDD4
0.9794
More...
Q9UBL6
Copine-7
ITCH
443:446
PPKY
ITCH,NEDD4
0.6593
More...
Q9UPG8
Zinc finger protein PLAGL2
ITCH
339:342
PPKY
ITCH,NEDD4
0.8841
More...
Q9Y2I6
Ninein-like protein
ITCH
99:102
PPKY
ITCH,NEDD4
0.5986
More...
Q9Y696
Chloride intracellular channel protein 4
ITCH
101:104
PPKY
ITCH,NEDD4
0.8903
More...
Q9BZD7
Transmembrane gamma-carboxyglutamic acid protein 3
ITCH
216:219
PPKY
ITCH,NEDD4
0.9823
More...
A8K0R7
Zinc finger protein 839
ITCH
140:143
PPKY
ITCH,NEDD4
0.8006
More...
Q2M218
Zinc finger protein 630
ITCH
212:215
PPKY
ITCH,NEDD4
0.5506
More...
Q5SZD1
Uncharacterized protein C6orf141
ITCH
154:157
PPKY
ITCH,NEDD4
0.7621
More...
Q8NDZ0
BEN domain-containing protein 2
ITCH
473:476
PPKY
ITCH,NEDD4
0.9633
More...
Q0VF49
Uncharacterized protein KIAA2012
ITCH
206:209
PPKY
ITCH,NEDD4
0.9964
More...
